Reta M®: MEGGLE´s first lactose-free co-processed excipient for modified release formulations

Reta M®: MEGGLE´s first lactose-free co-processed excipient for modified release formulations

13. October 2020

Co-processing specialist MEGGLE Excipients & Technology (MEGGLE) has developed Reta M®. The first hypromellose/mannitol-based, co-processed excipient specifically designed for direct...

De-risking excipient particle size distribution variability with automated robust mixing: Integrating quality by design and process analytical technology

8. October 2020

Particle size distribution (PSD) variability in excipients affects mixing. In response, manufacturers rely on raw material control and rigidly defined...

Investigation of the mucoadhesivity, swelling and drug release mechanisms of indomethacin buccal tablets: effect of formulation variables

7. October 2020

The purpose of this study was to investigate the effect of formulation variables on properties related to critical functionality for...

Implementation of formation mechanisms in DEM simulation of the Spheronization process of pharmaceutical pellets

19. September 2020

In the production process of pharmaceutical pellets with a narrow size distribution and a high sphericity, a combined extrusion-spheronization technique...

Applicability of impulse excitation technique as a tool to characterize the elastic properties of pharmaceutical tablets: experimental and numerical study

19. September 2020

Elastic properties are of particular interest during the development of tablets especially for the definition of the formulation and of...

StarlLac and FlowLac 100 direct tableting agents

Evaluation of Lactose-Based Direct Tableting Agents’ Compressibility Behavior Using a Compaction Simulator

14. September 2020

A compaction simulator (CS) is a single-punch instrument that records data during the powder compaction process. The aim of the...

Minitablet and a buccal mucoadhesive carrier film

A Novel Composite Dosage Form for Buccal Drug Administration

10. September 2020

The potential of alternative routes of application compared to the traditional oral route is constantly growing. Especially in transmucosal applications...

Raman Spectroscopy as a PAT-Tool for Film-Coating Processes: In-Line Predictions Using one PLS Model for Different Cores

30. August 2020

Although Raman spectroscopy has been described as a potential process analytical technique for tablet coating, it has rarely been transferred...

Conversion of α-lactose monohydrate to anhydrous form with superior tabletability by twin-screw extrusion at elevated temperature

23. August 2020

The purpose of this study was to improve tabletability (tensile strength versus compaction pressure) of α-lactose monohydrate by twin screw extrusion (TSE)...

Comparison of Different Liquid and Semisolid Vehicles Selected for Oral Administration of Pellets and Minitablets with Diazepam: In Vitro Investigation

6. August 2020

The acceptability and palatability of a dosage form are extremely important to improve patient compliance. Mixing oral solid dosage forms...

Meggle

Reta M®: MEGGLE´s first lactose-free co-processed excipient for modified release formulations

De-risking excipient particle size distribution variability with automated robust mixing: Integrating quality by design and process analytical technology

Investigation of the mucoadhesivity, swelling and drug release mechanisms of indomethacin buccal tablets: effect of formulation variables

Implementation of formation mechanisms in DEM simulation of the Spheronization process of pharmaceutical pellets

Applicability of impulse excitation technique as a tool to characterize the elastic properties of pharmaceutical tablets: experimental and numerical study

Evaluation of Lactose-Based Direct Tableting Agents’ Compressibility Behavior Using a Compaction Simulator

A Novel Composite Dosage Form for Buccal Drug Administration

Raman Spectroscopy as a PAT-Tool for Film-Coating Processes: In-Line Predictions Using one PLS Model for Different Cores

Conversion of α-lactose monohydrate to anhydrous form with superior tabletability by twin-screw extrusion at elevated temperature

Comparison of Different Liquid and Semisolid Vehicles Selected for Oral Administration of Pellets and Minitablets with Diazepam: In Vitro Investigation

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