Spray-freeze-drying aprepitant with hydroxypropyl cellulose increases nasal bioavailability

7. May 2026

Abstract The design of free-flowing lyophilized powders by spray-freeze-drying (SFD) enables novel therapeutic applications, including nasal administration. In this study,...

The uniform white appearance of the prepared Rebamipide-loaded deep eutectic mixture (DEM) granules.

In Silico Preformulation Modeling, Solubility Enhancement, and Sustainable Release of Rebamipide Utilizing Deep Eutectic Mixture Loaded Bioadhesive Controlled Release Granules for Gastritis Treatment

6. May 2026

Abstract Background/Objectives: Rebamipide is a gastroprotective agent with poor aqueous solubility and rapid gastrointestinal clearance, leading to reduced therapeutic efficiency. This...

A Two-Tier Protection Strategy for Oral Delivery of GLP-1 Peptides: Lipid-Based Formulation Combined with Enteric Capsules

4. May 2026

Abstract Oral delivery of peptides represents a promising alternative to invasive injectable therapies, offering improved patient adherence and convenience. Glucagon-like...

Comparison of HPMCAS Chemical Grades (L, M, and H) for Amorphous Solid Dispersion by Hot-Melt Extrusion. II: Polymer-Drug-Surfactant Miscibility and Drug Release with Itraconazole as a Model Drug

3. May 2026

Abstract Hydroxypropyl methylcellulose acetate succinate (HPMCAS) is commonly used to develop amorphous solid dispersions (ASDs), but its use is mostly...

Continuous 3D printing of medicines via a directly coupled twin-screw hot-melt extrusion printing system

2. May 2026

Abstract 3D printing drug formulations for personalized medicine is a growing research field and offers many opportunities to improve patient...

Incorporation of micronized poorly soluble drug into orodispersible tablets by aqueous fluid bed granulation of co-processed excipients

2. May 2026

Abstract The layering of active pharmaceutical ingredient (API) suspension on inert carriers through fluid bed granulation has been tackled in...

A Smart Ingestible Capsule for Real-Time Monitoring of Stimuli-Responsive Polymer Dissolution Kinetics and Oral Drug Release in the Gastrointestinal Tract

1. May 2026

Abstract Oral drug delivery relies on precise, site-specific release within the gastrointestinal (GI) tract, commonly achieved using stimuli-responsive polymer (SRP)...

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