Are Injection Site Reactions in Monoclonal Antibody Therapies caused by Polysorbate Excipient Degradants?

30. July 2018

30. July 2018 Injection site reactions (ISRs) and other adverse side-effects are commonly observed during therapy with biologics. These...

Solubilization of drugs using sodium lauryl sulfate: Experimental data and modeling

30. July 2018

30. July 2018 Micellar solubilization is a great method for increasing drugs solubility in aqueous environments. At concentrations above the...

Storage stability and solubilization ability of HPMC in curcumin amorphous solid dispersions formulated by Eudragit E100

27. July 2018

27. July 2018 The present study elucidated the advantages of using hydroxypropyl methylcellulose E5 (HPMC) as auxiliary excipient in...

ReForm Biologics Announces New Patent on Surfactant Replacement Excipients to Stabilize Antibody-Based Therapeutics

11. July 2018

11. July 2018 New surfactant replacement offers a promising alternative to polysorbates for stabilizing proteins CAMBRIDGE, Mass. – July 11,...

Qualtiy by Desgin development of Bosentan SNEDDS

QBD-based systematic development of Bosentan SNEDDS: Formulation, characterization and pharmacokinetic assessment

2. July 2018

02. July 2018 The aim of this study was to develop self-nanoemulsifying drug delivery system (SNEDDS) of bosentan using...

verview-graphic-for-the-gelucire-family-semi-solid-excipients-by-french-company-gattefosse

The Gelucire® family – semi-solid excipients by Gattefossé

18. June 2018

Gelucire® is Gattefossé’s brand of semi-solid excipients originally designed for hard gelatin capsule molding. The name results from the fusion...

overview-of-the-bioavailabilty-data-for-two-different-ways-of-drug-adminstration

Semisolid self-microemulsifying drug delivery systems (SMEDDSs): Effects on pharmacokinetics of acyclovir in rats

15. June 2018

15. June 2018 Semisolid self-microemulsifying drug delivery system (SMEDDS) with optimized drugloading capacity, stability, dispersibility in aqueous media and invitro drug release profile, was evaluated in...

graphic-which-shows-eight-different-typical-components-of-a-protein-formulation

Protein-excipient interactions evaluated via NMR studies in polysorbate based multi-dose protein formulations

12. June 2018

12. June 2018 Preservatives are excipients essentially needed in pharmaceutical multi-dose formulations to prevent microbial growth. Among available substances,...

Formulation of a microemulsion-based hydrogel containing celecoxib

3. December 2017

03. December 2017 The aims of this study are to prepare and characterize a microemulsion-based hydrogel containing celecoxib (CLX) for transdermal delivery. Pseudo-ternary...

The Development of Self-nanoemulsifying Liquisolid Tablets to Improve the Dissolution of Simvastatin

2. March 2017

02. March 2017 Abstract The aim of this work was to develop self-nanoemulsifying liquisolid tablets (SNELT) to enhance the dissolution...

Surfactants