Pharma Excipients
Sustained Release Agent
Injectable systems for long-lasting insulin therapy
Abstract
Insulin therapy is the mainstay to treat diabetes characterizedd by hyperglycemia. However, its short half-life of only 4–6 min limits its effectiveness in treating chronic diabetes. Advances in recombinant DNA technology and protein engineering have led to several insulin analogue…
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Investigations on Compaction Behavior of Kollidon®SR-Based Multi-component Directly Compressed…
The physics of tablets mixtures has gained much attention lately. The purpose of this work is to evaluate the compaction properties of Kollidon® SR (KSR) in the presence of different excipients such as Microcrystalline cellulose (MCC), Monohydrous lactose (MH Lactose), Poly (vinyl acetate) (PVA100),…
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Controlled release, chitosan-tethered luteolin phytocubosomes; Formulation optimization to in-vivo…
A chitosan-coated luteolin-loaded phytocubosomal system was prepared to improve the pharmacodynamic performance of luteolin in the treatment of glaucoma and ocular inflammation after topical ocular administration. Luteolin, a potent anti-oxidant herbal drug with poor aqueous solubility, was…
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MeltSerts Technology (Brinzolamide ocular inserts via hot-melt extrusion): QbD-steered development,…
The research work aimed to develop a robust sustained release biocompatible brinzolamide (BRZ)-loaded ocular inserts (MeltSerts) using hot-melt extrusion technology with enhanced solubility for glaucoma management. A 32 rotatable central composite design was employed for the optimization of the…
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Adult Patients with Difficulty Swallowing Oral Dosage Forms: A Systematic Review of the Quantitative…
Abstract
The aim of this systematic review was to identify and critically appraise the available evidence regarding solid oral dosage forms (SODFs), e.g., tablets, and challenges regarding the oral administration of medicine to inpatients in a variety of healthcare settings such as (1) hospitals,…
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Cyclodextrins and derivatives in drug delivery: New developments, relevant clinical trials, and…
Cyclodextrins (CD) and derivatives are functional excipients that can improve the bioavailability of numerous drugs. Because of their drug solubility improving properties they are used in many pharmaceutical products. Furthermore, the stability of small molecular drugs can be improved by the…
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Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery:…
Abstract
Oral delivery of peptides and biological molecules promises significant benefits to patients as an alternative to daily injections, but the development of these formulations is challenging due to their low bioavailability and high pharmacokinetic variability. Our earlier work focused on…
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Preparation of Sustained Release Formulation of Verapamil Hydrochloride Using Ion Exchange Resins
The purpose of this investigation was to formulate and evaluate the interaction between cation exchange resins and verapamil hydrochloride. The uptake studies were conducted using the rotating bottle apparatus. The Langmuir-like equation was applied to the experimental data and the maximum drug…
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Recent Progress in Diatom Biosilica: A Natural Nanoporous Silica Material as Sustained Release…
Abstract
A drug delivery system (DDS) is a useful technology that efficiently delivers a target drug to a patient’s specific diseased tissue with minimal side effects. DDS is a convergence of several areas of study, comprising pharmacy, medicine, biotechnology, and chemistry fields. In the…
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Controlled release mechanism of thymol loaded into mesoporous silica nanoparticles for active…
In order to overcome the poor water solubility and instability of thymol to enhance its bioavailability, mesoporous silica nanoparticles (MSNPs: SBA-15, SBA-16 and MCM-41) with different pore structures were developed using solution-gel method to carry and release thymol. The N2 …
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