excpients

Do you want to learn how to optimize immediate release formulations in terms of disintegration performance? Then register for our next free webinar: Formulate Robust, Fast Disintegrating Tablets with polyplasdone® crospovidone. Due to the complex interrelationships between raw material…
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An explanatory video by Prof. Simon Gaisford – Pharma Drama Welcome to Pharma Drama, the channel where we look at the science of healthcare and healthcare products. In this video I’m going to explain the concept of ideal solubility – so if that sounds ideal, get yourself a drink and then…
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Citric acid, a tricarboxylic acid, has found wide application in the chemical and pharmaceutical industry due to its biocompatibility, versatility, and green, environmentally friendly chemistry. This review emphasizes the pharmaceutical uses of citric acid as a strategic ingredient in drug…
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The purpose of this study was to develop a drug delivery system for paliperidone (PPD) in order to provide a more effective therapeutic strategy for patients with acute schizophrenia. PPD-loaded Soluplus®/TPGS mixed micelles (PPD-S/T-MM) were prepared using the thin-film hydration method. The…
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Apart from the fact that there are many different types of biologic products, at the moment there are not too many CDMOs able to manufacture drug substance and then produce a product, let alone that there are some CDMOs that don’t have commercial scale capabilities and some that do not have even…
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Developing solid oral drug products with good content uniformity (CU) at low doses is challenging; this challenge further aggravates when the tablet size decreases from a conventional tablet to a micro/mini-tablet (1.2 – 3mm diameter). To alleviate the CU issues, we present a novel use of…
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Parkinson’s disease (PD) affects around ten million people worldwide and is considered the second most prevalent neurodegenerative disease after Alzheimer’s disease. In addition, there is a higher risk incidence in the elderly population. The main PD hallmarks include the loss of dopaminergic…
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In an era moving towards digital health, 3D printing has successfully proven its applicability in providing personalised medicine through a technology-based approach. Among the different 3D printing techniques, direct extrusion 3D printing has been demonstrated as a promising approach for on demand…
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The biggest obstacle to the treatment of diseases that affect the central nervous system (CNS) is the passage of drugs across the blood-brain barrier (BBB), a physical barrier that regulates the entry of substances into the brain and ensures the homeostasis of the CNS. This review summarizes current…
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Introduction Polysorbates (PS) are used in biopharmaceuticals to stabilize therapeutic proteins. Oxidative degradation of (poly)unsaturated fatty acids (PUFAs) contained in PS was shown to lead to α,β-unsaturated carbonyls. Aim The n-6-PUFA linoleic acid accounts for up to 18% of all FAs…
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