Gattefosse

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, stabilizers, solubilizers, permeation enhancers and…
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Glyceryl behenate based-matrix tablets allowed obtaining a sustained release of theophylline for up to 12 hours. The diluent selected as pore-forming agent (lactose or dibasic calcium phosphate anhydrous) affected the drug release and its stability after 3-month storage at 40°. Lactose-containing…
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The lipolysis test is recommended during lipid-based formulation (LBF) development to evaluate whether the prototype formulations should be able to solubilize and maintain the drug in solution during the ‘in vivo’ digestion process. It is also a good tool to discriminate between formulations and…
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