Taste Masking Challenge of Solubility Enhancing Excipients – A Case Study

The major part (approx. 80%) of new drug actives are poorly soluble. Several techniques are used to enhance solubility including but lot limited to alternative salt forms, particle size reduction and solubility-enhancing excipients. Similar to APIs, many excipients are bitter or have other aversive sensory attributes including aromatic off-notes (malodor) and trigeminal irritation (e.g., tongue sting and mouth/throat burn). In some cases, the taste masking challenge of the excipient system can be greater than for the API itself.

Learn more in this article by David Tisi from Senopsys on the approaches to overcome the taste masking challenges of solubility enhancing excipients. Continue reading the full article on pharmaexcipients.com