Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion

18. November 2021

The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our...

Formulation of ternary genistein β-cyclodextrin inclusion complex: In vitro characterization and cytotoxicity assessment using breast cancer cell line

11. November 2021

Genistein (GT) is a poorly water-soluble flavonoid and reported for different biological activity. The present work was designed to prepare...

Monosaccharide-induced growth and higher order transitions in TPGS micelles

2. November 2021

D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) is a nonionic surfactant with low critical micelle concentration. It usually forms spherical core-shell...

Utilising Co-Axial Electrospinning as a Taste-Masking Technology for Paediatric Drug Delivery

Hepatoprotective, antioxidant and anti-inflammatory potentials of Vit-E/C@SeNPs in rats: Synthesis, characterization, biochemical, radio-biodistribution, molecular and histopathological studies

17. October 2021

This study aimed to synthesize a nano-structure between selenium, Vit. C, and Vit. E (Vit-E/C@SeNPs) as a promising protective and...

Biologic excipients: Importance of clinical awareness of inactive ingredients

14. October 2021

Due to the complexity and fragility of biological drug products, several challenges exist in their formulation development. Excipients are added...

Preparation scheme of ZgI-TPGS-liposomes.

TPGS-Modified Long-Circulating Liposomes Loading Ziyuglycoside I for Enhanced Therapy of Myelosuppression

18. September 2021

Background: Ziyuglycoside I (ZgI), an active ingredient isolated from traditional Chinese medicine Sanguisorba officinalis L, has been demonstrated to increase the leucocytes...

graphical abstract of Monitoring the microenvironment inside polymeric micelles using the fluorescence probe 6-propionyl-2-dimethylaminonaphthalene (PRODAN)

Monitoring the microenvironment inside polymeric micelles using the fluorescence probe 6-propionyl-2-dimethylaminonaphthalene (PRODAN)

17. September 2021

6-propionyl-2-dimethylaminonaphthalene (PRODAN) is a fluorescent molecule with sensitivity to environmental polarity and hydrogen bond interactions. Although it has been extensively...

graphical abstract of N-trimethyl chitosan coated nano-complexes enhance the oral bioavailability and chemotherapeutic effects of gemcitabine

N-trimethyl chitosan coated nano-complexes enhance the oral bioavailability and chemotherapeutic effects of gemcitabine

30. August 2021

N-trimethyl chitosan (TMC) is a multifunctional polymer that can be used in various nanoparticle forms in the pharmaceutical, nutraceutical and...

graphical abstract of Evaluation of the Antitumor Effect and Immune Response of Micelles Modified with a Polysialic Acid-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate Conjugate

Evaluation of the Antitumor Effect and Immune Response of Micelles Modified with a Polysialic Acid-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate Conjugate

28. August 2021

D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) has shown potential applications in cancer therapy owing to its attractive properties, including reversal...

graphical abstract of Vitamin E-tocopheryl polyethylene glycol succinate decorated drug delivery system with synergistic antitumor effects to reverse drug resistance and immunosuppression

Vitamin E-tocopheryl polyethylene glycol succinate decorated drug delivery system with synergistic antitumor effects to reverse drug resistance and immunosuppression

26. August 2021

To overcome cancer drug resistance and to reverse tumor immunosuppression, a vitamin E-tocopheryl polyethylene glycol succinate (TPGS) decorated polymer-based drug...

Vitamin E TPGS