Development of Apremilast Solid Dispersion Using TPGS and PVPVA with Enhanced Solubility and Bioavailability

30. April 2021

Apremilast (APST) is an effective inhibitor of phosphodieasterase 4 (PDE4) which is the first oral drug for the treatment of...

Radar plot of palatability results for swallowability, taste immediately after administration, texture and taste

The Development of Minitablets for a Pediatric Dosage Form for a Combination Therapy

22. April 2021

Minitablets are an appealing option for an age-appropriate pediatric dosage form. In particular, for combination therapies where multiple active ingredients...

Figure 4. IR overlay spectra of drug, polymer, mannitol, physical mixture & optimized DRV loaded NPs

Biodegradable polymeric nanocarriers for oral delivery of antiretroviral drug: Pharmacokinetic and in vitro permeability studies

18. April 2021

The current work aimed to formulate Darunavir (DRV) loaded poly (ɛ-caprolactone) nanoparticles (NPs) to address the issue of low bioavailability....

A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy

29. March 2021

Aim: The metastasis of breast cancer is an important cause of tumor recurrence. This study highlights that tyrosine kinase inhibitors...

graphical abstract of Development and Optimization of TPGS based Stealth Liposome of Doxorubicin Using Box-Behnken Design: Characterization, Hemocompatibility and Cytotoxicity Evaluation in Breast Cancer Cells

Development and Optimization of TPGS based Stealth Liposome of Doxorubicin Using Box-Behnken Design: Characterization, Hemocompatibility and Cytotoxicity Evaluation in Breast Cancer Cells

26. March 2021

The present work reports the development of doxorubicin (DOX) encapsulated α-Tocopherol polyethylene glycol 1000 succinate (TPGS) coated liposomal system (DOX-LIPO-TPGS)...

graphical abstract of Nose to brain delivery of tailored clozapine nanosuspension stabilized using (+)-alpha-tocopherol polyethylene glycol 1000 succinate: Optimization and in vivo pharmacokinetic studies

Nose to brain delivery of tailored clozapine nanosuspension stabilized using (+)-alpha-tocopherol polyethylene glycol 1000 succinate: Optimization and in vivo pharmacokinetic studies

24. March 2021

Clozapine is widely used to treat schizophrenia as an atypical antipsychotic. Low solubility, poor dissolution rate, degradation in the gastrointestinal tract, high...

Rp-HPLC Determination of Quercetin in a Novel D-α-Tocopherol Polyethylene Glycol 1000 Succinate Based SNEDDS Formulation: Pharmacokinetics in Rat Plasma

16. March 2021

Despite its proven efficacy in diverse metabolic disorders, quercetin (QU) for clinical use is still limited because of its low...

Enhancing in vitro cytotoxicity of doxorubicin against MCF-7 breast cancer cells in the presence of water-soluble β-cyclodextrin polymer as a nanocarrier agent

16. February 2021

This study was aimed to evaluate the impact of water-soluble β-cyclodextrin polymer (β-CDP), as a nanocarrier, on the therapeutic efficacy of...

Generation of Ophthalmic Nanosuspension of Prednisolone Acetate Using a Novel Technology

14. February 2021

Purpose Prednisolone Acetate (PAC) is currently marketed as micronized ophthalmic suspension. The microsuspension has poor dose accuracy and efficacy due...

Graphical representation of the different steps to obtain the Fx_NxCyA-ASNg formulations

Combination of Nanomicellar Technology and In Situ Gelling Polymer as Ocular Drug Delivery System (ODDS) for Cyclosporine-A

2. February 2021

A combination of in situ gelling systems and a loaded drug self-assembling nanomicellar carrier was chosen in this study as...

Vitamin E TPGS