The Preparation of Vitamin E Tablets with Fujicalin

Comparison with other commcierally available DCPAs

See the fourth issue of Fuji Chemical Industries Technical Newsletter. It presents the preparation of vitamin E tablets with Fujicalin® and a comparison with the other commercially available DCPAs.

Vitamin E is a fat-soluble vitamin like A, D and K. It is oily on physical appearance and exists either in the form of tocopherols or tocotrienols.

Powerful antioxidant primarily found in vegetable oils.
Associated with many health benefits.
Helps with the prevention of cardiovascular disease and cancer.
The recommended daily allowance (RDA) is 10-15 mg for adults.

By converting vegetable oils rich in vitamin E into a free flowing powder allows us to process them into capsules and tablets with advantages for both manufacturers and comsumers alike.

However, the amount of oily materials that can be adsorbed into a carrier is generally low, making it difficult to produce directly compressible tablets with an optimum load.

Silicates and other ingredients such as microcrystalline cellulose (MCC) and maltodextrin have been recommended for oil adsorption. The oil loading capacities of these excipients are comparatively low, which affects the flowability, compatibility, and compressibility of tablets.

The Preparation of Vitamin E Tablets with Fujicalin_SEM

Fujicalin® is ideal for both pharmaceutical and nutraceutical applications and is categorized as a Generally Recognized as Safe (GRAS) material.

In this edition of our newsletter, we compare the vitamin E adsorbent properties and tablettability of Fujicalin® to that of other commercially available DCPAs.

Figure 1. SEM photomicrographs of Fujicalin® and other DCPA´s from USA, Europe and Japan.

Thanks to spray-dry technology Fujicalin® particles have a very smooth surface leading to less abrasion (wear and tear) and longer life of tableting equipment.

Oil to Powder: Vitamin E Example

Continue reading and see the full Pharmaceutical Technical Newsletter on “Issue 04 – Vitamin E Tablets with Fujicalin®” here:

(click the picture to download the technical newsletter)