Apinovex Polymers Enable Solubility With Ease
Apinovex™ polymers can be easily incorporated into your drug project via spray drying or other solvent-based processes. This novel excipient has a broad API and solvent compatibility to produce Amorphous Solid Dispersions (ASD) of your brick-dust API.
Solubility-enhancing polymers for oral amorphous solid dispersions
Lubrizol Life Science Health’s (LLS Health’s) ApinovexTM polymers are high molecular weight linear polyacrylic acids that enhance the solubility of BCS Class II and IV APIs.
Formulation Benefits
- High, stable drug loading (up to 80%) via spray drying.
- Significantly improved drug release profile compared to crystalline APIs.
- Enables IP protection and 505(b)(2) formulations/ lifecycle management.
Processing Benefits
- Designed for standard spray drying and solvent-based processing.
- Soluble in water and common pharmaceutical solvents.
- Produces low viscosity solutions for ease of processing.
Competitive Advantages
• 2x more drug loading than other solubility-enhancing excipients (Soluplus® and AFFINISOL™ HPMC).
• Up to 10x improvement in dissolution for Apinovex dispersions compared to crystalline APIs.
• Stable amorphous solid dispersions, even after 6 months under accelerated conditions.
Key Properties
Solvent Compatibility
Apinovex polymers are soluble in common pharmaceutical solvents
Product Details
• Chemistry: High molecular weight polyacrylic acid
• Form: White powder
• Quality: IPEC Excipient GMP
Oral Safety Profile
Apinovex chemistry is similar to LLS Health’s IID-listed Carbopol® polymers, which have been used in oral drug products for decades.
See the full One Pager on “Apinovex™ Polymers” here
(click the picture to download the brochure)
Source: Lubrizol One Pager “Apinovex™ Polymers”
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