Numerical evaluation of the capping tendency of microcrystalline cellulose tablets during a diametrical compression test – Abstract
Capping is one of the major problems that occur during the tabletting process in the pharmaceutical industry. This study provided an effective method for evaluating the capping tendency during diametrical compression test using the finite element method (FEM). In experiments, tablets of microcrystalline cellulose (MCC) were compacted with a single tabletting machine, and the capping tendency was determined by visual inspection of the tablet after a diametrical compression test.