Comprehensive study of co-processed excipient F- Melt®: Flow, viscoelastic and compacts properties

This article aims to compare three commercially available co-processed excipients (CPEs), namely the F-Melt® type C, M and F1. All three CPEs were subjected to the evaluation of their physical properties and afterwards compacts were prepared using three compression pressures. The viscoelastic properties and ejection force were assayed during the compression and the compacts were evaluated in compliance with the European Pharmacopoeia and subjected to other relevant testing (AFM imaging, wettability etc.).


Comparing properties of bulk F-Melt® (C, M a F1) and prepared compacts.

C: lowest hygroscopicity, lowest lubricity.

M: highest tensile strength and the slowest disintegration.

F1: best flowability, highest lubricity.

All excipients are suitable for direct compression of orodispersible tablets.

Based on the obtained results it could be stated that the C and M have very similar properties according to their similar composition. In general, it is difficult to select the best CPE as they possess different properties fitting the versatile needs of manufacturers. However, the obtained results revealed that the M and F1 are more suitable for the incorporation of moisture-sensitive ingredients than the C. More on Comprehensive study of co-processed excipients F- Melt®: Flow, viscoelastic and compacts properties


See the F-Melt® functions also in this video:


Request a sample

You might also like