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Co-processed excipients
Applicability of Expert System for Drug Development as a tool for co-processed excipients…
Expert System for Drug Development, i.e. SeDeM Expert System (Span. Sistema Experto para DEsarrollo de Medicamentos) represents a method intended for evaluation of powder properties affecting processability, particularly compression behavior (Pérez et al., 2006). Additionally, it is recognized as…
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Applicability of Co processed Excipient to ODT prepared by Direct Compression Continuous…
Introduction
Continuous Manufacturing (CM) is a manufacturing method in which raw materials or blended materials enter the manufacturing process continuously, and products are discharged continuously throughout the duration of the process1). CM can yield required quantities of products with desired…
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PharSQ® Spheres CM – Unique starter spheres for controlled drug release by Budenheim
Technical information:
PharSQ® Spheres CM by Budenheim is a unique co-processed material made of substances fully compliant with pharmacopoeial requirements:
80% w/w Anhydrous dibasic calcium phosphate (Ph.Eur.,USP/NF, JP)
20% w/w Microcrystalline cellulose (Ph.Eur.,USP/NF, JP)
Available…
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Using twin-screw melt granulation to co-process mannitol and hydroxypropylcellulose
With the advent of continuous manufacturing, twin-screw melt granulation has attracted interest in the pharmaceutical industry as a method for co-processing excipients and developing new formulations. Twin-screw melt granulation relies on the heat and shear produced by the viscous and frictional…
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New and Novel Excipients – Part 2
A week ago I wrote about the importance of new and novel excipients for the pharmaceutical industry and presented Klucel™ xtend and BioSustane™ in last week´s edition of "The Excipients Week".
In the meantime I launched a small poll with the title "Was there innovation in excipients over the last…
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DiCom SANAQ® SP205 / SP206 – Co-processed excipient for direct compression of hygroscopie and…
PHARMATRANS SANAQ offers excipients and active ingredients of outstanding quality and performance. With our research & development skill and tradition, we commit to study innovative technological solutions providing excipients contributing successfully to smart and efficient pharmaceutical…
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Formulation Strategies to Improve the Stability and Handling of Oral Solid Dosage Forms of Highly…
Highly hygroscopic pharmaceutical and nutraceutical solids are prone to significant changes in their physicochemical properties due to chemical degradation and/or solid-state transition, resulting in adverse effects on their therapeutic performances and shelf life. Moisture absorption also leads to…
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Why not choose DC co-processed excipients in your ODT formulation?
Direct compression (DC) is the simplest process to manufacture tablets. The advantage of DC is that the simplicity of the manufacturing process can reduce manufacturing costs and manufacturing time. On the other hand, we often encounter challenges, such as tableting trouble, tablet weight…
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Co-processed excipients: Recent advances and future perspective
The demands on the functionality of excipients are increasing day by day because of the emergence of high-speed tableting machines and the use of direct compression methods for tableting. Co-processing plays an important role in the development of a stable excipient with multifunctional activity.…
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Control of Drug-Excipient Particle Attributes with Droplet Microfluidic-based Extractive…
Purpose
Industrial implementation of continuous oral solid dosage form manufacturing has been impeded by the poor powder flow properties of many active pharmaceutical ingredients (APIs). Microfluidic droplet-based particle synthesis is an emerging particle engineering technique that enables the…
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