Co-processed excipients

Co-processed dry binders for ODTs are important multifunctional excipients for tablet manufacturing by direct compression. Testing their binary mixtures with lubricants is an important aspect of their use in combination with drugs. The aim of this study was to evaluate the rheological and…
Read More...

Pharmatrans Sanaq has added SANAQ® SP 205/206 to its DiCom range of Co-Processed Excipients supporting Direct Compression (DC) applications. DiCom SANAQ®  SP205 and SP206 are both based on microcrystalline cellulose (MCC), co-processed with colloidal silicon dioxide (CSD) and Povidone K30…
Read More...

The utilization of co-processed excipients (CPEs) represents a novel approach to the preparation of orally disintegrating tablets by direct compression. Flow, consolidation, and compression properties of four lactose-based CPEs - Cellactose® 80, CombiLac®, MicroceLac® 100, and StarLac®- were…
Read More...

This work presents the evaluation of a co-processed material for high-load dose formulations and its real-time monitoring by near-infrared (NIR) spectroscopy at the tablet press feed frame. The powder and tableting properties of co-processed material blends were evaluated and compared to the blend…
Read More...

Pediatric, geriatric, and other patients who suffer from swallowing difficulties represent a special patient group, where an increased need in appropriate formulation development is required. To overcome these mostly swallowability linked issues, orodispersible tablets (ODTs) and orodispersible…
Read More...

Obtaining orodispersible tablets (ODT) containing substances from the 2nd Biopharmaceutical Class has raised concerns as the dissolution test is challenging. This study aimed to select suitable excipients for developing orodispersible tablets containing cannabidiol (CBD) by direct compression…
Read More...

Fuji Chemical Industries specializes in producing porous spray-dried excipients for the pharmaceutical and nutraceutical markets. We spray-dry our excipients to produce free-flowing granules and unique internal structures that enhance compressibility and functionality. Our products are ideal when it…
Read More...

Background Computer-aided formulation design is gaining fantastic attention in chemical engineering of high functionality pharmaceutical materials for dosage form manufacture. To accelerate development of novel formulations in a quality-by-design perspective, SeDeM Expert System preformulation…
Read More...

Pharmatrans Sanaq has now added DICOM SP 204 tailored to help formulation development of moisture sensitive APIs and to stabilize formulations where alkaline conditions need to be controlled to its DICOM SANAQ® range of high functionality co-processed excipients. SANAQ® SP 204  is a co-processed…
Read More...

As commonly known, the product development stage is quite complex, requires intensive knowledge, and is time-consuming. The selection of the excipients with the proper functionality and their corresponding levels is critical to drug product performance. The objective of this study was to apply…
Read More...