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Co-processed excipients
Use of Two-Factor Dispersion Analysis for Studying the Pharmaceutical and Technological Properties…
The influence of the type and ratio of co-process fillers and lubricating excipients on the properties of the final dosage form was studied during the development of the composition and technology for GK-2 tablets dispersed in the oral cavity.
The pharmaceutical and technological properties,…
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Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible…
Development of orodispersible minitablets (ODMTs) requires consideration of aspects related to small dimensions, while ensuring short disintegration time with sufficient mechanical stability. In order to meet these and other critical quality attributes (CQAs), quality by design is encouraged.…
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GRANFILLER-D™ Water Absorption Behavior and Disintegration Mechanism
In the formulation design of conventional orally disintegrating tablets (ODTs) by direct compression, disintegratablity often reduces when active pharmaceutical ingredient (API) content is high. Since API tends to block the gap between particles in tablets, which is considered to be the main water…
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Quantitative analysis of blend uniformity within a Three-Chamber feed frame using simultaneously…
This study reports the use of Raman and Near-infrared (NIR) spectroscopy to simultaneously monitor the drug concentration in flowing powder blends within a three-chamber feed frame. The Raman probe was located at the top of the dosing chamber, while the NIR probe was located at the top of the…
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An update on microcrystalline cellulose in direct compression: Functionality, critical material…
Microcrystalline cellulose (MCC) is one of the most popular cellulose derivatives in the pharmaceutical industry. Thanks to its outstanding tabletability, MCC is generally included in direct compression (DC) tablet formulations containing poor-tabletability active pharmaceutical ingredients.…
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Solving Compactability Issues for the Preparation of ODTs
Introduction
Formulators often face compactability issues for the preparation of orally disintegrating tablets (ODTs) where active pharmaceutical ingredients (APIs) are poorly compressible or formed in a coated pellet. HiSORAD™, one of the best-in-class co-processed excipient for ODT, may work as…
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Comparative evaluation of mechanical properties of lactose-based excipients co-processed with…
The introduction of the high-speed tableting machines and the lack of excipients with good flow and compaction properties required for direct compression process have increased research interest in the development of co-processed excipients. Melt granulation, as an environmentally friendly and…
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Characterization of excipients to improve pharmaceutical properties of sirolimus in the…
Enhanced drug release and bioavailability of poorly soluble active pharmaceutical ingredient (API) can be achieved via a fluidized bed coating integrated with supercritical anti-solvent (SAS-FB) – a process of precipitating drug particles onto carrier granules. However, in the absence of excipients,…
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Evaluation of the Disintegrant Properties of Silicified Oryza sativa Starch Co-Processed with…
Starch is a readily available excipient which finds application in the pharmaceutical industry as binders, diluents and disintegrants. The use of starch is however limited by its poor flow characteristics. Co-processing exploits the desirable attributes of excipients, while masking the undesirable…
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Pharmatrans excipients for improved compactibility and flowability in tablet manufacture
Pharmatrans SANAQ AG specializes in pharmaceutical excipients and active ingredients, harnessing a spirit of innovation and commitment to high quality products based on a solid platform of experience established over almost four decades.
The Pharmatrans SANAQ product portfolio includes a range of…
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