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Copovidone
Phase homogeneity in ternary amorphous solid dispersions and its impact on solubility, dissolution…
Abstract
As performance of ternary amorphous solid dispersions (ASDs) depends on the solid-state characteristics and polymer mixing, a comprehensive understanding of synergistic interactions between the polymers in regard of dissolution enhancement of poorly soluble drugs and subsequent…
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Design of Redispersible High-Drug-Load Amorphous Formulations: Impact of Ionic vs Nonionic…
Amorphous solid dispersions (ASDs) are an enabling formulation approach used to enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich amorphous nanoparticles generated in situ during ASD dissolution maintain supersaturation that drives enhanced absorption.…
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Quantification of Soluplus® and copovidone polymers in dissolution media: Critical systematic review
Polymer-based solid dispersions including amorphous solid dispersions (ASD) are viable strategies to enhance the release of poorly soluble drugs. The concurrency of the drug and polymer release and the concentration of polymer in dissolution media directly influence the drug release and the…
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The influence of hydrogen bonding between different crystallization tendency drugs and PVPVA on the…
Abstract
Amorphous solid dispersion (ASD) is one of the formulation strategies for drugs displaying low solubility and low oral bioavailability. In this study, high drug-loaded ASDs of drugs with different crystallization tendencies were prepared by spray drying. The aim was to investigate the…
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Accessing amorphous solid dispersions for improved Solubility and Bioavailability in paediatric…
This article shows the content of a poster which was presented at the 𝗘𝗨𝗣𝗳𝗜 𝗰𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 𝗶𝗻 𝗚𝗹𝗮𝘀𝗴𝗼𝘄 2023
Introduction
BCS class II drugs show a low solubility. Modern paediatric formulations are needed to obtain high acceptance of patients at recommended daily doses
Hot-melt extrusion (HME)…
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Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed…
The aim of this study is to investigate the influence of polymer chemistry on the properties of oral dosage forms produced using selective laser sintering (SLS). The dosage forms were printed using different grades of polyvinyl alcohol or copovidone in combination with indomethacin as the active…
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Review of industrially recognized polymers and manufacturing processes for amorphous solid…
Evolving therapeutic landscape through combinatorial chemistry and high throughput screening have resulted in an increased number of poorly soluble drugs. Drug delivery strategies quickly adapted to convert these drugs into successful therapies. Amorphous solid dispersion (ASD) technology is widely…
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Numerical simulation of five different screw configurations used during the preparation of hot-melt…
This work developed immediate-release hot melt extruded pellets containing the poorly aqueous soluble drug Indomethacin with five different screw configurations for oral application. Moreover, numerical simulation concerning residence time was performed for each configuration to give valuable tools…
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Viscoelastic Behavior of Supercooled and Glassy ASDs at Humid Conditions Can Be Predicted
Amorphous solid dispersions (ASDs) are commonly used to increase the dissolution rate of poorly soluble active pharmaceutical ingredients (APIs). Unfortunately, most ASDs are thermodynamically unstable and, even though kinetically stabilized, will thus eventually crystallize. The crystallization…
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3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and…
Nowadays, a high number of pipeline drugs are poorly soluble and require solubility enhancement by e.g., manufacturing of amorphous solid dispersion. Pharmaceutical 3D printing has great potential in producing amorphous solid oral dosage forms. However, 3D printing techniques differ greatly in terms…
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