All4Nutra
Abstract
A strategy based on sequential design of experiments (screening, optimization and confirmation) was used to develop a tablet formulation of ibuprofen (400 mg) that is manufactured by direct compression. This formulation has a high content of ibuprofen (76%), in spite of the poor flowability of the drug substance. Sequential design of experiments proved to be an effective and efficient strategy in formulation development.
Socorro Alpizar-Ramos1 and Mario González-de la Parra2*
1School of Chemistry, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico 2Biokinetics, S.A. de C.V., Mexico City, Mexico; [email protected]
1School of Chemistry, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico 2Biokinetics, S.A. de C.V., Mexico City, Mexico; [email protected]
