Pharma Excipients
DC excipient
Enhancement of dissolution rate and oral bioavailability of poorly soluble drug florfenicol by using…
Abstract
Objective: Florfenicol(FF) is an excellent veterinary antibiotic, limited by poor solubility and poor bioavailability.
Significance: Here in, we aimed to explore the applicability of fast disintegrating tablets compressed from Florfenicol-loaded solid dispersions (FF-SD-FDTs) to improve…
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Revolutionary Advancements in Fast Dissolving Tablets: An In-Depth Exploration
ABSTRACT
A novel drug delivery system plays a pivotal role in enhancing patient adherence to medication regimens. Among these innovative approaches, fast dissolving tablets (FDT’s) stand out as a particularly promising option. FDT’s offer a range of benefits, including precise dosing, ease of…
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Monitoring low dose API blend uniformity with Parteck® M mannitol using near-infrared (NIR)…
Direct compression is often used for tablet manufacturing because it is the shortest, most effective, and least complex method. The physical properties of active pharmaceutical ingredients (APIs) can, however, create a challenge for flowability and compressibility, and, as a result, affect tablet…
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More than just Tableting – Our Granules for Direct Compression
With DC Granules, Dr. Paul Lohmann produces a line that is ideally suitable for direct tableting for pharmaceutical applications.
Granulation enlarges the particle size, converting fine or coarse powders into physically strong and larger granules with uniform shape, good flow property as well as…
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Elucidating the Impact of Material Properties on Tablet Manufacturability for Binary Paracetamol…
Abstract
Purpose
Although the mechanical properties of paracetamol and MCC are extensively described in literature, there still is a need for a better understanding of the material properties impacting them. Thus, this study systematically analyzed material properties of paracetamol-MCC blends…
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VITAMIN E – Direct Compression with PROSOLV 730
Aim of the study
Solid dose formulations of Vitamin E, an oily active ingredient, are typically produced as soft-gel capsules in the pharmaceutical and nutraceutical industry. The manufacturing process of these soft-gel capsules is labor-intensive and costly. The goal of this study was to create…
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Investigations on Compaction Behavior of Kollidon®SR-Based Multi-component Directly Compressed…
The physics of tablets mixtures has gained much attention lately. The purpose of this work is to evaluate the compaction properties of Kollidon® SR (KSR) in the presence of different excipients such as Microcrystalline cellulose (MCC), Monohydrous lactose (MH Lactose), Poly (vinyl acetate) (PVA100),…
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Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation
Abstract
Freeze-drying of biopharmaceutical products is the method of choice in order to improve their stability and storage conditions. Such Freeze-dried products are usually intended for parenteral route administration. However, many biopharmaceutical materials administered by parenteral route…
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Effect of magnesium stearate solid lipid nanoparticles as a lubricant on the properties of tablets…
Abstract
This study discusses the lubricant properties of magnesium stearate solid lipid nanoparticles (MgSt-SLN) and their effect on the tabletability, mechanical properties, disintegration, and acetaminophen-model dissolution time of microcrystalline cellulose (MCC) tablets prepared by direct…
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The Development of Oral Solid Dosage Forms Using the Direct-Compression Tableting of Spray-Dried…
Abstract
This study addresses the challenge of developing a cheap, patient-friendly alternative to antibiotics using bacteriophages for gastrointestinal applications. It explores the feasibility of manufacturing an enteric solid dosage form containing a salmonella-specific Myoviridae phage, Felix…
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