DC excipient

Abstract This study investigates the improvements in direct compaction powder properties achieved through particle design using laboratory and pilot-scale spray dryers. Hydroxypropyl methylcellulose and polyvinylpyrrolidone were used as modifying agent, which have low hygroscopicity and surface…
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Abstract Background/Objectives: Improving the production rates of modern tablet presses places ever greater demands on the performance of excipients. Although co-processing has emerged as a promising solution, there is still a lack of directly compressible excipients for modified-release…
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Introduction Direct tableting Lactose is widely used as an excipient in tableting applications due to inert chemical properties, as well as its superior compression and compaction characteristics. Direct tableting is widely used in the pharmaceutical industry due to it’s simplicity versus other…
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Abstract In this work, real-time optimization (RTO) schemes are proposed and applied on a continuous pharmaceutical manufacturing process which consists of three units: synthesis unit, hot melt extrusion unit and direct compaction line. The developed RTO strategies calculate the operating…
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Abstract The pharmaceutical industry is continuously looking for strategies and solutions that can improve quality and efficiency of manufacturing processes. As a result, there has been a significant shift towards continuous manufacturing (CM). Traditionally, tablets have been produced by batch…
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Abstract Mesoporous silica offers an easy way to transform liquids into solids, due to their high loading capacity for liquid or dissolved active ingredients and the resulting enhanced dissolution properties. However, the compression of both unloaded and loaded mesoporous silica bulk material into…
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This poster was presented at the DDF Summit Conference 2024 by Valentyn MOHYLYUK, Zoltán Márk HORVÁTH, Kirils KUKULS, Liga LAUBERTE, Artūrs PAULAUSKS from Rīga Stradiņš University: Introduction Replacing batch wet granulation with twin-screw melt extruder as a continuous solventless process is…
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This study aimed to advance the development of intestinal colon-coated sustained-release matrix tablets of metronidazole for diverticulitis treatment, employing the Quality by Design (QbD) methodology. Comprehensive Risk analysis and Risk evaluation were conducted to assess the potential risks…
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The challenges of developing good quality low dose minitablets was assessed by systematically studying the effects of ibuprofen (IBU, a model compound) particle sizes (6–58 µm D50) and concentrations (0.1–3 %w/w), roller compaction forces (3–7 kN/cm), and the minitablet size. A novel compression…
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Used for over 100 years, pharmaceutical lactose is a milk sugar produced from cheese whey or milk permeate streams through a process of crystallisation, purification, milling and sieving. Today, it is well-established and commonplace in the pharmaceutical industry due to the numerous advantages of…
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