Pharma Excipients
DC excipient
CBD Oil Tablets Chewable – Direct Compression with PROSOLV 730
Aim of the Study
Due to the physico-chemical properties of cannabidiol (CBD), the vast majority of the marketed products containing CBD are oils. To provide greater convenience in dosing, the goal of this experiment was to make directly compressible 25 mg CBD oil tablets as well as 25…
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Novel bioequivalent oral disintegrating tablet of aripiprazole prepared by direct compression…
Herein, we aimed to formulate a novel oral disintegrating tablet (ODT) of aripiprazole (ARP) capable of rapid disintegration using a direct compression technique. Different ODTs were fabricated with directly compressible excipients, and their disintegration time, wettability (water absorption ratio…
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Development of direct compression Acetazolamide tablet with improved bioavailability in healthy…
Abstract
Pharmaceutical cocrystallization has been widely used to improve physicochemical properties of APIs. However, developing cocrystal formulation with proven clinical success remains scarce. Successful translation of a cocrystal to suitable dosage forms requires simultaneously improvement of…
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Using AI/ML to predict blending performance and process sensitivity for Continuous Direct…
Utilising three artificial intelligence (AI)/machine learning (ML) tools, this study explores the prediction of fill level in inclined linear blenders at steady state by mapping a wide range of bulk powder characteristics to processing parameters. Predicting fill levels enables the calculation of…
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PEARLITOL® 200 GT Mannitol: Harnessing the Potential of Higher Active Ingredient Content for…
INTRODUCTION
Mannitol is the first intention excipient for oral solid forms, designed for APIs having stability problems. Mannitol is not hygroscopic and presents a high chemical stability; therefore, it is considered compatible with almost all drugs.
To combine its high stability properties…
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Case Study PEARLITOL® 200 GT Mannitol: A Tool to Formulate Mini Tablets as a Compliant and Flexible…
PURPOSE
Mini tablets are a multiple unit dosage form with a size of less than 3.0 mm in diameter with great flexibility to deliver appropriate doses to the pediatric age group. They can be given in different numbers, according to dosage requirements, with no special prerequisite of formulating age…
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Enhancement of dissolution rate and oral bioavailability of poorly soluble drug florfenicol by using…
Abstract
Objective: Florfenicol(FF) is an excellent veterinary antibiotic, limited by poor solubility and poor bioavailability.
Significance: Here in, we aimed to explore the applicability of fast disintegrating tablets compressed from Florfenicol-loaded solid dispersions (FF-SD-FDTs) to improve…
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Revolutionary Advancements in Fast Dissolving Tablets: An In-Depth Exploration
ABSTRACT
A novel drug delivery system plays a pivotal role in enhancing patient adherence to medication regimens. Among these innovative approaches, fast dissolving tablets (FDT’s) stand out as a particularly promising option. FDT’s offer a range of benefits, including precise dosing, ease of…
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Monitoring low dose API blend uniformity with Parteck® M mannitol using near-infrared (NIR)…
Direct compression is often used for tablet manufacturing because it is the shortest, most effective, and least complex method. The physical properties of active pharmaceutical ingredients (APIs) can, however, create a challenge for flowability and compressibility, and, as a result, affect tablet…
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More than just Tableting – Our Granules for Direct Compression
With DC Granules, Dr. Paul Lohmann produces a line that is ideally suitable for direct tableting for pharmaceutical applications.
Granulation enlarges the particle size, converting fine or coarse powders into physically strong and larger granules with uniform shape, good flow property as well as…
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