Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus

30. January 2025

Abstract Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance, leading to elevated blood sugar levels....

Experimental and Theoretical Design on the Development of Matrix Tablets with Multiple Drug Loadings Aimed at Optimizing Antidiabetic Medication

30. December 2024

Abstract Background: Diabetes is a growing global health crisis that requires effective therapeutic strategies to optimize treatment outcomes. This study aims...

Core-shell aerogel design for enhanced oral insulin delivery

18. December 2024

Abstract Current protein-based therapies often rely on intravenous and subcutaneous injections leading to patient discomfort due to the need for...

Development of dual drug loaded-hydrogel scaffold combining microfluidics and coaxial 3D-printing for intravitreal implantation

8. October 2024

Abstract Treating diabetic retinopathy (DR) effectively is challenging, aiming for high efficacy with minimal discomfort. While intravitreal injection is the...

Recent advances in polymer-based nanoformulations for enhancing oral drug delivery in diabetes

3. October 2024

Diabetes is a long-term metabolic disorder caused by issues with insulin production or response in the body. This leads to...

Encapsulation of bioactive compounds in foods for diabetics – sources, encapsulation technologies, market trends and future perspectives – A systematic review

18. August 2024

Diabetes is a metabolic disorder characterized by hyperglycemia and is a disease with an increasing prevalence. Hyperglycemia triggers abnormalities in...

Experimental Investigation on Efficacy of Eudragit RS 100 Polymer in Prolonging Glibenclamide Release by Intragastric Floating Microsphere Formulation and Physicochemical Evaluation

27. July 2024

Abstract Background: The amalgamation of targeted transportation and enhancement of the release profile of the active pharmaceutical ingredient is a...

Preparation of nanoparticle and nanoemulsion formulations containing repaglinide and determination of pharmacokinetic parameters in rats

21. July 2024

Abstract Repaglinide (RPG) belongs to the class of drugs known as meglitinides and is used for improving and maintaining glycemic...

Formulation and dermal delivery of a new active pharmaceutical ingredient in an in vitro wound model for the treatment of chronic ulcers

1. July 2024

The aim of this study was to investigate dermal delivery of the new active pharmaceutical ingredient (API) TOP-N53 into diabetic...

Oral Delivery of Liraglutide-Loaded Zein/Eudragit-Chitosan Nanoparticles Provides Pharmacokinetic and Glycemic Outcomes Comparable to Its Subcutaneous Injection in Rats

24. May 2024

Abstract Liraglutide (LIRA) is a glucagon-like peptide-1 (GLP-1) receptor agonist renowned for its efficacy in treating type 2 diabetes mellitus...

Diabetes