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Diabetes
Long-acting Parenteral Drug Delivery Systems for the Treatment of Chronic Diseases
Abstract
The management of chronic conditions often requires patients to take daily medication for an extended duration. However, the need for daily dosing can lead to nonadherence to the therapy, which can result in the recurrence of the disease. Long-acting parenteral drug delivery systems have…
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Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems
Poor medication adherence is a pervasive issue with considerable health and socioeconomic consequences. Although the underlying reasons are generally understood, traditional intervention strategies rooted in patient-centric education and empowerment have proved to be prohibitively complex and/or…
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Intranasal Insulin Delivery: Microparticle Formulations Consisting of Aloe vera Polysaccharides for…
Aloe vera gel and whole leaf materials, as well as polysaccharides, precipitated from the gel, have previously been shown to enhance macromolecular drug delivery across epithelial tissues. This study investigated the effectiveness of microparticle formulations prepared from A. vera polysaccharides…
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Development of Clinically Optimized Sitagliptin and Dapagliflozin Complex Tablets: Pre-Formulation,…
The purpose of this study is to derive an optimal drug release formulation with human clinical bioequivalence in developing a sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixed-dose combination (FDC) tablet as a treatment for type 2 diabetes mellitus. As a treatment for type 2…
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Development of Imeglimin Electrospun Nanofibers as a Potential Buccal Antidiabetic Therapeutic…
The prevalence of type 2 diabetes (T2D) has been growing worldwide; hence, safe and effective antidiabetics are critically warranted. Recently, imeglimin, a novel tetrahydrotriazene compound, has been approved for use in T2D patients in Japan. It has shown promising glucose-lowering properties by…
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3D Printed Pharmaceutical Systems for Personalized Treatment in Metabolic Syndrome
The current healthcare system is widely based on the concept of “one size fit for all”, which emphasizes treating a disease by prescribing the same drug to all patients with equivalent doses and dosing frequency. This medical treatment scenario has shown varied responses with either no or weak…
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Design, development, in-vitro and in-vivo evaluation of polylactic acid-based multifunctional…
Impaired healing of diabetic ulcers is one of the major complications of diabetic patients due to high susceptibility to microbial infections, impaired lymphianogenesis, edema, and consequently impairing proper healing. This could even lead to much worse complications that include severe gangrene,…
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Formulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro…
Repaglinide (RPG), a monotherapy insulin secretagogue used to treat diabetes mellitus-type II yet, it suffers from poor water solubility and variable bioavailability (∼ 50%) due to hepatic first pass metabolism. In this study, 2FI I-Optimal statistical design was employed to encapsulate RPG into…
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Particle-Based therapies for antigen specific treatment of type 1 diabetes
Type 1 diabetes mellitus (T1D) is the leading metabolic disorder in children worldwide. Over time, incidence rates have continued to rise with 20 million individuals affected globally by the autoimmune disease. The current standard of care is costly and time-consuming requiring daily injections of…
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Development, in vitro Evaluation, and in vivo Study of Adhesive Buccal Films for the Treatment of…
Objective: Development and evaluation of bucco-adhesive films of Gliclazide for pediatric use.
Methods: Sixteen films were formulated using a different combination of Gelatin, Hydroxy propyl methyl cellulose (HPMC), polyvinyl alcohol, Hydroxy propyl cellulose (HPC), chitosan, polyethylene glycol,…
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