Comprehensive Investigation of a Famotidine/Captisol Inclusion Complex: Formulation, Characterization, and Enhanced Bioactivity

Abstract

In this research, with the aim of improving the solubility and bioavailability of famotidine, the inclusion complex of famotidine with the Captisol (sulfobutyl ether β-cyclodextrin) was prepared using the freeze-drying method.

The formation of the complex was confirmed by infrared spectrometry and proton nuclear magnetic resonance (HNMR). The results obtained from the Job method and phase solubility studies using ultraviolet spectroscopy method, the stoichiometric ratio of the famotidine/Captisol complex was determined to be 1:1.

The stability constant of the complex was calculated according to the Benesi-Hildebrand method (1526.3 dm³·mol^–1). Examination of the infrared spectrum and the two-dimensional proton nuclear magnetic resonance spectrum (2D-HNMR) showed that the famotidine molecule is completely inside the hydrophobic cavity of Captisol.

The surface morphology of famotidine/Captisol complex, was investigated using by scanning electron microscopy (SEM). The antioxidant and antibacterial properties as well as drug release behavior of tablet of famotidine/Captisol complex were investigated.

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Yaghini, Y., Arvand, M. & Arvand, B. Comprehensive Investigation of a Famotidine/Captisol Inclusion Complex: Formulation, Characterization, and Enhanced Bioactivity. J Solution Chem (2026). https://doi.org/10.1007/s10953-026-01608-x