System model driven selection of robust tablet manufacturing processes based on drug loading and formulation physical attributes

graphical abstract of System model driven selection of robust tablet manufacturing processes based on drug loading and formulation physical attributes

System model driven selection of robust tablet manufacturing processes based on drug loading and formulation physical attributes

25. February 2022

Mechanistic process modeling presents an opportunity to reduce experimental burden, enabling relationships between process parameters and product attributes to be...

Figure 1. scheme of roll compaction with D: roll diameter, N: nip width, S: gap width, T: ribbon thickness, α: nip angle.

Improving Process Understanding in Roll Compaction

12. February 2022

Roll compaction/ dry granulation is gaining importance. Numerous papers have been published and many attempts to model the process are available in...

Sampling and diversion strategy for twin-screw granulation lines using batch statistical process monitoring

26. January 2022

Continuous manufacturing is now considered as a well-established technique by pharmaceutical companies. However, the limited number of filed applications reflects...

Relationship between powder properties and uniformity of ribbon property using feeding guider designs with thermography (PAT) in roller compaction

21. January 2022

Roller compaction is a continuous dry granulation process in which two counter-rotating rollers compress the powder. The feeding of powder...

In-Depth Understanding of Granule Compression Behavior under Variable Raw Material and Processing Conditions

18. January 2022

Tablet manufacturing involves the processing of raw materials through several unit operations. Thus, the mitigation of input-induced variability should also...

graphical abstract of The Effect of Binder Types on the Breakage and Drying Behavior of Granules in a Semi-Continuous Fluid Bed Dryer after Twin Screw Wet Granulation

The Effect of Binder Types on the Breakage and Drying Behavior of Granules in a Semi-Continuous Fluid Bed Dryer after Twin Screw Wet Granulation

17. January 2022

Current study investigated the effect of different binder types on the granule drying process and the granule breakage behavior in...

The effect of screw configuration and formulation variables on liquid requirements and granule quality in a continuous twin screw wet granulation process

13. January 2022

The effect of two screw configurations with varying stagger angle was evaluated on the liquid amount required to produce good...

Streamlining the development of an industrial dry granulation process for an immediate release tablet with systems modelling

29. December 2021

In industrial practice, the development of pharmaceutical dry granulation processes typically involves time- and resource-intensive multivariate experiments. These experiments are...

figure 2 of Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of tablets on the basis of characteristics of granules prepared by high shear wet granulation

Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of tablets on the basis of characteristics of granules prepared by high shear wet granulation

21. December 2021

High shear wet granulation is commonly applied technique for commercial manufacturing of tablets. Granulation process for tablets manufacturing is generally...

Material characteristics after dry granulation using roller compaction: A) urea particle size distribution, B) appearance of granulated urea following a 12-month stability study and C) appearance of potassium chloride following a 12-month stability study.

Application of Dry Granulation to Facilitate Raw Material Handling

20. December 2021

Pharmaceutical and biopharmaceutical manufacturing relies on the timely and seamless orchestration of many steps to meet aggressive timelines and ensure...

Granulation

System model driven selection of robust tablet manufacturing processes based on drug loading and formulation physical attributes

Improving Process Understanding in Roll Compaction

Sampling and diversion strategy for twin-screw granulation lines using batch statistical process monitoring

Relationship between powder properties and uniformity of ribbon property using feeding guider designs with thermography (PAT) in roller compaction

In-Depth Understanding of Granule Compression Behavior under Variable Raw Material and Processing Conditions

The Effect of Binder Types on the Breakage and Drying Behavior of Granules in a Semi-Continuous Fluid Bed Dryer after Twin Screw Wet Granulation

The effect of screw configuration and formulation variables on liquid requirements and granule quality in a continuous twin screw wet granulation process

Streamlining the development of an industrial dry granulation process for an immediate release tablet with systems modelling

Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of tablets on the basis of characteristics of granules prepared by high shear wet granulation

Application of Dry Granulation to Facilitate Raw Material Handling

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