Granulation

High shear wet granulation (HSWG), as a widely used granulation technology, has been studied extensively. However, for the HSWG of...

In this study, a hybrid modeling framework was developed for predicting size distribution and content uniformity of granules in a...

Introduction Formulators often face compactability issues for the preparation of orally disintegrating tablets (ODTs) where active pharmaceutical ingredients (APIs) are...

Wet granulation process is a major unit operation in production of pharmaceuticals as solid dosage oral formulation. Indeed, granulation is...

In this study, we developed a control strategy for a drug product prepared by high-shear wet granulation and roller compaction...

Fluid bed granulation (FBG) is used extensively in the pharmaceutical industry and it is known to be a complex process, because the...

The present paper serves as a demonstration how an in-line PAT tool can be used for rapid and efficient process...

An amorphous solid dispersion (ASD) of sorafenib (SOR) in hydroxypropyl methylcellulose acetate succinate (HPMC-AS), prepared by coprecipitation, was used to...

During wet granulation, the sample can be exposed to considerable mechanical effects, moisture content and elevated temperatures, and during high-shear...

Using discrete element method (DEM) modeling and near-infrared (NIR) spectroscopy, the feasibility of powder mixing in the initial pre-melting zones...