Paliperidone palmitate as model of heat-sensitive drug for long-acting 3D printing application

25. March 2022

In this work, two technologies were used to prepare long-acting implantable dosage forms in the treatment of schizophrenia. Hot-melt extrusion...

Embedding a Sensitive Liquid-Core Waveguide UV Detector into an HPLC-UV System for Simultaneous Quantification of Differently Dosed Active Ingredients during Drug Release

22. March 2022

Individual dosing of pharmaceutics and personalized medicine have become important with regard to therapeutic safety. Dose adjustments, biorelevant drug release...

Cellulose-based sustained-release mini-matrices of highly water-soluble drug via hot-melt extrusion technology

Formulation performance window for manufacturing cellulose-based sustained-release mini-matrices of highly water-soluble drug via hot-melt extrusion technology

3. March 2022

The aim of the proposed work was to develop robust hot-melt extrusion (HME) process for fabricating sustained-release mini-matrices (pellets) of...

Figure 10. The changes of the 3D-printed tablets during dissolution: pictures of the tablet before (A) and after (B) freeze-drying process, CT images of cross section (C) and vertical section (D) of the tablet.

Design, Preparation and In Vitro Evaluation of Core–Shell Fused Deposition Modelling 3D-Printed Verapamil Hydrochloride Pulsatile Tablets

20. February 2022

The aim of the study was to investigate core–shell pulsatile tablets by combining the advantages of FDM 3D printing and...

Solubility enhancement – Transform insoluble drugs into stable and efficient formulations

15. February 2022

Recent industry trends show many pharmaceutical manufacturers are creating drugs with greater degrees of lipophilicity, higher molecular weight, greater physical...

graphical abstract of 3D printing of pharmaceutical oral solid dosage forms by fused deposition: the enhancement of printability using plasticised HPMCAS

3D printing of pharmaceutical oral solid dosage forms by fused deposition: the enhancement of printability using plasticised HPMCAS

9. February 2022

3D printing (3DP) by fused deposition modelling (FDM) is one of the most extensively developed methods in additive manufacturing. Optimizing...

FDM 3D-Printed Sustained-Release Gastric-Floating Verapamil Hydrochloride Formulations with Cylinder, Capsule and Hemisphere Shapes, and Low Infill Percentage

7. February 2022

The aim of this work was to design and fabricate fused deposition modeling (FDM) 3D-printed sustained-release gastric-floating formulations with different...

Factors Influencing the Crystallization-Onset Time of Metastable ASDs

2. February 2022

In formulation development, amorphous solid dispersions (ASD) are considered to improve the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs)....

graphical abstract of Precise Dosing of Pramipexole for Low-Dosed Filament Production by Hot Melt Extrusion Applying Various Feeding Methods

Precise Dosing of Pramipexole for Low-Dosed Filament Production by Hot Melt Extrusion Applying Various Feeding Methods

26. January 2022

The aim of this research was the production of low-dosed filaments via hot-melt extrusion (HME) with the model drug pramipexole...

Hot-melt extruded hydroxypropyl methylcellulose acetate succinate based amorphous solid dispersions: Impact of polymeric combinations on supersaturation kinetics and dissolution performance

24. January 2022

Nucleation inhibition and maintenance of drug supersaturation over a prolonged period are desirable for improving oral absorption of amorphous solid...

Hot-melt extrusion