Hot-melt extrusion

The FDA-approved anthelmintic flubendazole has shown potential to be repositioned to treat cancer and dry macular degeneration; however, its poor...

High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely known, extended-release polymers. Conventional high-molecular-weight HPMCs are preferred in extended-release applications...

Tablets used for extended drug release commonly contain large amounts of drugs. The corresponding drug release mechanism thus has to...

The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we...

3d printing is capable of providing dose individualization for pediatric medicines and translating the precision medicine approach into practical application....

The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our...

Filaments loaded with griseofulvin (GF), a model poorly water-soluble drug, were prepared and used for 3D printing via fused deposition...

The present study explored vacuum drum drying (VDD) as an alternative technology for amorphous solid dispersions (ASDs) manufacture compared to...

Highlights • The mechanical and rheological properties are limiting steps for FFF. • Increasing the VA content showed lower buckling stress,...

The selection of an appropriate polymer for the preparation of amorphous solid dispersions via hot-melt extrusion (HME) deals with the...