Pharma Excipients
Calcium Carbonate
Omya launches new excipients for nutraceutical tablets
Minerals supplier Omya International AG (Switzerland) announced it will launch two new nutraceutical tablet excipients at this year’s Vitafoods Europe trade show taking place in October. Both new excipients are designed to overcome processing challenges for dietary supplements and improve ease of…
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Calcium Carbonate as Functional Filler in Polyamide 12 – Manipulation of the Thermal and…
Adjusting the thermal response properties of a polymeric compound can significantly improve the usability in a selective laser-sintering process. As previously shown, combining a precise amount of coarse and narrow size distribution fine calcium carbonate fillers results in a potential optimization…
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High Acceptability of an Orally Dispersible Tablet Formulation by Children
There is a high unmet medical need for child-appropriate oral dosage forms. The acceptability of a novel placebo orally dispersible tablet formulation (pODT) was therefore evaluated. Monolithic tablets contain an inorganic calcium carbonate/calcium phosphate carrier material as the main excipient.…
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In vitro characterization and mouthfeel study of functionalized calcium carbonate in orally…
Orally disintegrating tablets (ODT) are comfortable and safe drug delivery methods beneficial for all age groups of patients. ODTs are characterized by fast disintegration, high physical stability, taste masking and acceptable mouthfeel. In this work, the applicability of Functionalized Calcium…
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Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and…
Uniform drug distribution within fast disintegrating tablets is a key quality measure to ensure a reliable, steady, and targeted release of the contained active pharmaceutical ingredients. In this work, the drug particle distribution in mini-tablets was studied with synchrotron phase contrast X-ray…
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Stabilization of amorphous drugs – are crystalline inorganic excipients a way forward?
Physical instability arguably is the major challenge in using neat amorphous active pharmaceutical ingredients in everyday tablets and capsules. The conversion of an amorphous form to the crystalline state either during storage or drug dissolution constitutes physical instability of amorphous drugs,…
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Use of calcium carbonate as an excipient for release of poorly water soluble drugs: The case of…
Carbamazepine (CBZ) is a poorly water soluble drug owing to the Biopharmaceutic Classification System (BCS) class II. It is characterized by a variable bioavailability and by the presence of different polymorphs. In this paper the effects of CaCO3 on the physicochemical properties of CBZ and its…
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Functionalised calcium carbonate as a coformer to stabilize amorphous drugs by mechanochemical…
The aim of this study was to investigate the amorphization, physical stability and drug release of a model drug, carvedilol (CAR), when loaded onto functionalised calcium carbonate (FCC) using mechanochemical activation (vibrational ball milling). The solid-state characteristics and physical…
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Water-assisted synthesis of mesoporous calcium carbonate with a controlled specific surface area and…
A carbonation process to control the specific surface area of mesoporous calcium carbonate and the dissolution profile of ferulic acid on mesoporous carbonate particles are presented. The effects of water content on the physicochemical properties, specific surface area, pore size, crystallinity, and…
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Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet…
Fast disintegrating tablets have commonly been used for fast oral drug delivery to patients with swallowing difficulties. The different characteristics of the pore structure of such formulations influence the liquid transport through the tablet and hence affect the disintegration time and the…
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