Pharma Excipients
Liquids
Lyophilized Lipid Liquid Crystalline Nanoparticles as an Antimicrobial Delivery System
Lipid liquid crystalline nanoparticles (LCNPs) are unique nanocarriers that efficiently deliver antimicrobials through biological barriers. Yet, their wide application as an antimicrobial delivery system is hindered by their poor stability in aqueous dispersions. The production of dried LCNP powder…
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Formulation and in vitro skin diffusion of colchicine using different drug delivery vehicles
Introduction
Historically known as “the disease of kings,” gout is one of the oldest known types of arthritis, affecting more than 40 million people worldwide, prevalent in patients between 30 and 50 years of age, and frequently experienced more by males than females , , , ]. It is a result of…
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Formulating with Self-Emulsifying Cream Bases: Kolliphor® CSL
Kolliphor® CSL (cetostearyl alcohol, sodium lauryl sulfate, and sodium cetostearyl sulfate) by BASF is an emulsifier and structuring agent combination product that is suitable for O/W (oil-in-water) formulations.
Its strategically designed self-emulsifying properties allow it to be used in…
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Putting children first: Understanding caregivers’ and children’s perspectives on the usability of…
A multi-national online survey was developed to obtain feedback on users’ experiences of administration devices for oral and inhaled paediatric medicines. The questionnaire was divided into two identical parts: 1) for caregivers looking after children aged 0–18 years, and 2) for children aged 10 …
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Dual drug loaded nanostructured lipid carrier for cytotoxic effect against breast cancer-a drug…
Abstract
In the present study nanostructured lipid carrier with a combination of Metformin (MET) and Thymoquinone (THY) was developed, characterized, and was further evaluated for cytotoxic effect on breast cancer cells. The optimized MET-THY-NLCs were found with the size 78.99 nm with entrapment…
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Deep Learning-Based Machine Vision System for Use in High-Shear Granulation
Aim
Develop a prototype machine vision system and evaluate feasibility of a deep learning-based image analysis approach for estimation of the state of granulation on the acquired granule bulk surface images.
Introduction
Despite many decades of research in granulation technology, the…
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Critical Excipients in Topical and Parenteral Dermatological Formulations: Novel Analytical…
Background & Introduction
Excipients play a crucial role in efficacy, safety and quality of medicinal products. In topical dermatological formulations, often complex excipients of natural or semi-synthetic origin with broad specifications are used (1). In parenteral drug delivery, non-ionic…
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How to ensure a successful tablet coating formulation development by using polyvinyl alcohol and…
Purpose
Recent ban of titanium dioxide (TiO2; E171) for the use in food and nutritional supplements (European Commission). The regulation includes a commitment to review the necessity of titanium dioxide as a white colorant in medicinal products1.
It is challenging to find a suitable…
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Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance
Abstract
The pharmaceutical industry is undergoing a paradigm shift towards continuous processing from batch, where continuous direct compression (CDC) is considered to offer the most straightforward implementation amongst powder processes due to the relatively low number of unit operations or…
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Nano-and Microfabrication Techniques in Drug Delivery – Insights Part 3
Nano-and Microfabrication Techniques in Drug Delivery
See the new book, edited by Dimitrios Lamprou. It brings together technical, clinical, regulatory and industrial perspectives. It provides future prospective and includes the potential clinical applications of nano/microfabrication technologies.…
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