Objective: The main objective of this review is to investigate the potential role of milk in improvement of bioavailability and patient compliance.

Method: The study reviews the types of milk based on its composition, mechanism of how milk improves the solubility of poorly soluble drugs, masks the taste of bitter drugs and improves the patient compliance to dosage regimen. It also reviews various research studies done so far that recommend the use of milk in formulations. Along with this, the regulatory aspect of using milk is also considered in the present study.

Conclusion: Investigation concludes that medicated milk formulations open a new hope of utilizing

milk as multi-functional drug carrier for a variety of drugs.

Key words: Milk, Solubility, Bitter, Casein, Fat, Pediatric