A Comprehensive Review On Formulation And Evaluation Of Chewable Tablet

Abstract

Chewable tablets are a specialized oral solid dosage form designed to be chewed in the mouth prior to swallowing, offering an effective alternative to conventional tablets. They are particularly advantageous for pediatric, geriatric, and dysphagic patients who experience difficulty in swallowing intact dosage forms. The primary objective of chewable tablet formulation is to enhance patient compliance by improving palatability, ease of administration, and overall acceptability. These tablets are formulated to disintegrate smoothly upon chewing, enabling faster drug release and, in some cases, improved bioavailability. The development of chewable tablets involves the careful selection of excipients such as directly compressible diluents (e.g., mannitol), sweeteners (natural or artificial), flavoring agents, and lubricants to mask the unpleasant taste of active pharmaceutical ingredients and provide a pleasant mouthfeel. The mechanical properties of the tablet, including hardness and low friability, are critical to ensure stability during handling, packaging, and transportation, while still allowing easy chewability.

Preformulation and formulation strategies play a vital role in achieving uniform drug distribution, optimal compressibility, and stability. Various manufacturing techniques such as direct compression and wet granulation are commonly employed. Post-compression evaluation parameters including weight variation, hardness, friability, disintegration time, content uniformity, and in vitro drug release studies are essential to assess the quality, safety, and efficacy of the formulation. In conclusion, chewable tablets represent a promising and patient-centric drug delivery system that combines convenience, improved taste masking, and reliable therapeutic performance, making them an important dosage form in modern pharmaceutical development.

Introduction

Introduction to chewable tablets: Oral route is most preferred route of administration due to its ease of administration, Patient compliance, Patient acceptance, accurate dosing and its cost effectiveness.The research on oral dosage forms is currently focused on improving the palatability and easy of administration especially in case of children and elderly patients.[1] Chewable tablets which are needed to be broken masticated in between the teeth before ingestion. These tablets are given to the children who have difficulty swallowing and to the grown-ups who dislike swallowing. These tablets are intended to disintegrate easily in mouth at a moderate rate either with or without factual chewing characteristically chewable tablets have a smooth texture upon decomposition, are affable tasting and leave no bitter or unwelcome taste.

These tablets are given to the children who have difficulty in swallowing and to the adults who dislikes swallowing. Chewable tablets have emerge as a promising alternative to address these limitations, offering improved patient acceptability, faster drug absorption inhance therapeutic efficacy. Chewable tablets are allowing for pre- gastric absorption and improved dissolution of active pharmaceutical ingredients.These tablets are particularly beneficial for pediatric and geriatric patients, as well as individuals with dysphagia, a condition that affects the ability to swallow solid dosage forms.[3]

Micronized and submicron forms of therapeutically and physiologically active substances increasingly being incorporated into tablet formulations to take advantage of the improved absorption properties of these forms. They are also used in the administration of antacids and carminative. Mannitol is widely used as an excipient in chewable tablets due to its non-hygroscopic properties for moisture-sensitive drugs. Successful development of a tablet formulation requires careful selection of ingredients to create a robust solid dosage form. Selection of appropriate excipients to perform specific functions in tablet formulations.Both natural and synthetic sweeteners are types of functional Excipients commonly used in the formulation of chewable tablets to mask unpleasant tastes and facilitate administration to children.

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Sonali M. Patil, Dr.Surajj Sarode (2026) A COMPREHENSIVE REVIEW ON FORMULATION AND
EVALUATION OF CHEWABLE TABLET. World Journal of Pharmaceutical Science and Research, 5(6), 254-264.