The aim of this study is the development and characterization of multiparticulate dosage forms which release MPT, a β-blocker, at a controlled rate. In order to achieve this goal, a solid dispersion is made by embedding MPT in a fatty acid matrix (behenic acid and myristic acid) via extrusion and prilling. The release out of the matrix is diffusion-based. Since controlled release dosage forms allow a lower dosing frequency and exhibit less side effects compared to immediate release dosage forms, patient compliance is improved.
Apr. Cathérine DEVIAENE
Master of Science in Industrial Pharmacy
GHENT UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES
Department of Pharmaceutics
Laboratory for Pharmaceutical technology
Academic year 2014-2015
Master of Science in Industrial Pharmacy
GHENT UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES
Department of Pharmaceutics
Laboratory for Pharmaceutical technology
Academic year 2014-2015










































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