Design, Development and Evaluation of Novel Nanoemulgel for Topical Drug Delivery System
Abstract
Objective: The present study is aimed to design, development of nanoemulgel and evaluate for topical drug delivery system. Nanoemulgel prove to be promising carrier for intense amount of poorly penetrable drugs to produce their effect topically.
Methods: FTIR-study was performed to determine compatibility of drug with excipients. Various oil-in-water nanoemulsions are prepared by the homogenization method. Prepared nanoemulsions were characterized for its particle size, polydispersity index, SEM, TEM, pH, drug content, and In-Vitro drug diffusion study, etc. Based on its In Vitro drug diffusion study optimized formulation showed higher release compared to other formulations. Incorporating the optimized nanoemulsion with gel base to produce nanoemulgel and characterize for homogeneity, pH, viscosity, spreadability, In-Vitro drug diffusion study, stability study, and antifungal study.
Results: The FTIR-study confirmed that there was no interaction between drug and excipients. The optimized nanoemulsion (NF3) exhibited particle size 208.6nm with PDI index 0.648, drug content 90.12% and in-vitro release of 87.95% at 12 hr. The prepared nanoemulgel was homogenous, transparent yellow with good spreadability 68.5, viscosity 52500, pH 6.5. The drug release at 8 hr was 72.01%.
Conclusion: Hence, it can be concluded that nanoemulgel of luliconazole can provide better antifungal activity and improve patient compliance.
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Materials
Luliconazole was obtained as gift sample from Akums Drugs and Pharmaceuticals Ltd Delhi, India. Labrafac were procured from Gattefosse. All the other chemicals used were of analytical grade.
Design, Development and Evaluation of Novel Nanoemulgel for Topical Drug Delivery System, Manure Hirakant and Dr. Nagoba Shivappa N., Journal of Biomechanical Science and Engineering, Japan Society of Mechanical Engineers, ISSN: 1880-9863, July Issue: Theme 1
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