Method Development Technology and Optimisation Studies in Famotidine Pellets: An In Vitro Release
Oral medication administration has long been the most convenient and widely utilized technique of drug administration. Pellets are fine powders or granules of bulk pharmaceuticals and excipients agglomerated together. They are made up of tiny, freeflowing spherical or semi-spherical solid units that range in size from 0.5 to 1.5mm. These are normally meant to be taken by mouth. Thus, Famotidine has been chosen to prepare pellet formulations employing polymers such as HPMC, Eudragit, and HPC in this study. To analyze and estimate the drug in buffers and acid media, calibration curves were constructed using UV at 306 and 286nm respectively.
The flow properties like the angle of repose, bulk density, tapped density; Carr’s index, and h-ratio were found to be within the pharmacopeia’s guidelines. 12 formulations ranging from F1-F12 were prepared with various concentrations and types of polymers. The drug loading in all the formulations was estimated using HPLC and was found to be satisfactory. The pellets had a smooth surface and uniform drug loading, according to SEM examination. In vitro, drug release tests were conducted, and the F13 and F14 formulations reported the best release based on previous results. The improved formulation was further subjected to release kinetics testing. Formulations are appropriate for releasing medicine into the upper intestine and stomach, according to the research. According to the findings of this investigation, the developed sustained drug delivery system might be used for a variety of water-insoluble pharmaceuticals.
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Deevan Paul A , Vivek Morris Prathap , Tabish Qidwai , Niranjan Podili , Kritika Pandey , Mandapati Lavanya
Journal of Positive School Psychology, 2022, Vol. 6, No. 4, 10373–10390