Advances in Nanocarrier Systems for Overcoming Formulation Challenges of Curcumin: Current Insights
Abstract
Curcumin, an organic phenolic molecule that is extracted from the rhizomes of Curcuma longa Linn, has undergone extensive evaluation for its diverse biological activities in both animals and humans. Despite its favorable characteristics, curcumin encounters various formulation challenges and stability issues that can be effectively…
Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of…
Solid lipid microparticles (SLMs) represent a promising approach for drug delivery in anti-acne applications. In this study, asiatic acid-loaded SLMs (AASLMs) were prepared by melt emulsification method in conjunction with freeze-drying.…
Fabrication and characterization of shellac nanofibers with colon-targeted delivery of quercetin and…
In this study, the feasibility of shellac nanofibers as carrier system for colonic delivery of quercetin was evaluated. Firstly, the nanofibers without and with different amounts (2.5 %, 5.0 %, and 7.5 %) of quercetin were fabricated using…
Spray-Dried Chitosan Hydrogel Particles as a Potential Delivery System for Benzydamine Hydrochloride
Abstract
Chitosan, being a biocompatible and mucoadhesive polysaccharide, is one of the most preferred hydrogel-forming materials for drug delivery. The objectives of the present study are to obtain spray-dried microparticles based on…
Evaluation of Monolayer and Bilayer Buccal Films Containing Metoclopramide
Abstract
The objective of this study was to develop buccal film formulations containing metoclopramide hydrochloride monohydrate (MCP) with and without a backing layer and to evaluate their release properties and physiochemical stability.…
Customizable orodispersible films: Inkjet printing and data matrix encoding for personalized…
Abstract
The aim of this study was to exploit the versatility of inkjet printing to develop flexible doses of drug-loaded orodispersible films that encoded information in a data matrix pattern, and to introduce a specialised data…
Overcoming the Low-Stability Bottleneck in the Clinical Translation of Liposomal Pressurized…
Abstract
Currently, several types of inhalable liposomes have been developed. Among them, liposomal pressurized metered-dose inhalers (pMDIs) have gained much attention due to their cost-effectiveness, patient compliance, and accurate…
Chitosan-(poly)acrylic acid polyelectrolyte complexes: Enhanced mucoadhesion and sustained drug…
Polyelectrolyte complexes (PECs) have emerged as promising vehicles for medical applications, attributable to their non-toxicity, non-immunogenicity, and ability for controlled drug release. Notably, their inherent mucoadhesive properties…
Ternary solid dispersions of lacidipine: Enhancing dissolution and supersaturation maintenance…
The study aimed to address the challenges related to insufficient dissolution and maintenance of supersaturation in binary solid dispersions. Lacidipine, categorized as a BCS class II drug, was employed as the model drug. A systematic…
Polymeric Nanohydrogel in Topical Drug Delivery System
Nanohydrogels (NH) are biodegradable polymers that have been extensively studied and utilized for various biomedical applications. Drugs in a topical medication are absorbed via the skin and carried to the intended location, where they are…
Twin-Screw Melt Granulation with PEG 8000: effect of binder particle size and processing temperature…
Introduction
High-drug-loaded tablets and capsules are desirable and are manufactured using granulation as an additional step. Replacing batch wet granulation with twin-screw melt extruder as a continuous solventless process is gaining…
The science of pharmaceutical suspensions explained! – Explainer video by Pharma Drama
In this video Pharma Drama aka Prof. Simon Gaisford explains how suspensions are formulated and what the medicine is trying to achieve in terms of their properties.
See the video and read the full transcript below.
Read the …
Colon-targeted 3D-Printed mesalamine tablets: Core-shell design and in vitro/ex-vivo evaluation
Abstract
Objectives
The present study is intended to develop a shell-core tablet using a hot melt extrusion (HME)-based dual-nozzle fused deposition modeling (FDM) three-dimensional (3D) printing approach. The primary objective was to…
A Multi-Particulate Formulation of Pantoprazole Based on Enteric Coated Minitablets
JRS Pharma presented three posters at the 2024 PBP World Meeting in Vienna. This is the first poster:
Introduction
Multiparticulate systems provide solutions to some of the main challenges found with gastro-resistant formulations, namely…
Fabrication of 3D-Printed Hydrocortisone Triple Pulsatile Tablet Using Fused Deposition Modelling…
Hydrocortisone (HC) is the optimal drug for adolescents diagnosed with congenital adrenal hyperplasia (CAH). Because traditional dosage regimens HC are inconvenient, our study used fused deposition modeling (FDM) three-dimensional (3D)…
Formulation, Characterization and In Vitro Evaluation of Mesalamine and Bifidobacterium bifidum…
Mesalamine is a first-line drug for the treatment of inflammatory bowel diseases. However, its premature release associated with marketed formulations leads to adverse effects like gastric trouble, vomiting, and diarrhoea. To minimize these…
BASF Pharma Solutions introducing a new shear protectant – Kolliphor® P188 Cell Culture
On March 11th, 2024, BASF Pharma Solutions officially announced the launch of Kolliphor® P188 Cell Culture – This new shear protectant is a GMP material for bioprocessing applications where a lower average molecular weight poloxamer could…
Implementation of near-infrared spectroscopy and convolutional neural networks for predicting…
Monitoring the particle size distribution (PSD) is crucial for controlling product quality during fluidized bed granulation. This paper proposed a rapid analytical method that quantifies the D10, D50, and D90 values using a Convolutional…
Vitamin E & TPGS Reimagined: ADM’s Novatol® and Decanox® Solutions
The sky’s the limit with ADM’s Novatol® naturally derived Decanox® mixed tocopherols and vitamin E. These powerful and plant-based antioxidants are the ideal way to help protect cells in the body from oxidative stress. Further, Novatol®…
Overcome Challenges of Elastic Deformation with the Right Excipient – Case Study With…
Abstract
Developing a medicine in which the active ingredient has elastic deformation is always challenging, as elastic forces affect the compression capacity of the formulation, resulting in tablets with capping, low tablet breaking force…
Skin-friendly textures – by Gattefossé
Caring for patients
Patient preferences and needs as well as therapeutic indication should be considered at early stage of development of topical or transdermal formulations.
To increase adherence to skin treatments, it is important…
Mesoporous Silica as an Alternative Vehicle to Overcome Solubility Limitations
Abstract
Toxicological studies are a part of the drug development process and the preclinical stages, for which suitable vehicles ensuring easy and safe administration are crucial. However, poor aqueous solubility of drugs complicates…
What are pharmaceutical hydrates and solvates? – Explainer video by Pharma Drama
In this video, Pharma Drama aka Prof. Simon Gaisford will explain what hydrates and solvates are and why both are important in the design of medicines.
See the video and read the full transcript below.
Full video…
Troubleshooting and FAQs for KLEPTOSE® β-cyclodextrins and hydroxypropyl-β-cyclodextrins
See some Frequently Asked Questions and the corresponding answers for Cyclodextrins and KLEPTOSE®:
What are ß-Cyclodextrins (ß-CDs)?
β-Cyclodextrins (β-CDs) are cyclic oligosaccharides with a bucket-like structure having a hydrophobic…
Novel SmartReservoirs for hydrogel-forming microneedles to improve the transdermal delivery of…
Hydrogel-forming microneedles (HF-MNs) are composed of unique cross-linked polymers that are devoid of the active pharmaceutical ingredient (API) within the microneedle array. Instead, the API is housed in a reservoir affixed on the top of…
A strategy to optimize precompression pressure for tablet manufacturing based on in-die elastic…
A precompression pressure optimization strategy using in-die elastic recovery was developed to effectively address tablet lamination caused by air entrapment. This strategy involves exacerbating the air entrapment issue using high tableting…
The Role of BARETab Nutra DS in Direct Tablet Compression Method
BARETab Nutra DS is a novel Co-Processed excipients which is a combination of three Pharmacopeial excipients made by Co-Processing Technology. BARETab Nutra DS contains Dibasic Calcium Phosphate Anhydrous (Filler), Microcrystalline…
Topical co-delivery of tacrolimus and calcipotriol loaded nanostructured lipid carrier: a potential…
The focus of this study was to develop a Vitamin-D3 (Calcipotriol)-based Tacrolimus (TAC)-loaded nanostructured lipid carrier (NLC) for topical application to treat psoriasis. The sonication technique followed by melt emulsification was…
Fabrication of a Controlled-Release Core-Shell Floating Tablet of Ketamine Hydrochloride Using a 3D…
In this study, a novel floating, controlled-release and core-shell oral tablet of ketamine hydrochloride (HCl) was produced using a dual extrusion by 3D printing method. A mixture of Soluplus® and Eudragit® RS-PO was extruded by a hot-melt…
The Effect of Formulation Variables on the Manufacturability of Clopidogrel Tablets via Fluidized…
Solid pharmaceutical formulations with class II active pharmaceutical ingredients (APIs) face dissolution challenges due to limited solubility, affecting in vivo behavior. Robust computational tools, via data mining, offer valuable insights…
Simplex Lattice Design and Machine Learning Methods for the Optimization of Novel Microemulsion…
Novel p-coumaric acid microemulsion systems were developed to circumvent its absorption and bioavailability challenges. Simplex-lattice mixture design and machine learning methods were employed for optimization. Two optimized formulations…
Maltodextrin-Based Cross-Linked Electrospun Mats as Sustainable Sorbents for the Removal of Atenolol…
Abstract
Maltodextrins are products of starch hydrolysis that can be processed into dry fibres through electrospinning and subsequently cured via mild thermal treatment to obtain nonwoven cross-linked polysaccharide-based mats. The…
Influence of Nozzle Geometry and Scale-Up on Oil Droplet Breakup in the Atomization Step during…
Spray drying of oil-in-water emulsions is a widespread encapsulation technique. The oil droplet size (ODS) significantly impacts encapsulation efficiency and other powder properties. The ODS is commonly set to a specific value during…
Roquette signs agreement to acquire IFF Pharma Solutions
La Madeleine (France), 19 March 2024 – Roquette, a global leader in plant-based ingredients and pharmaceutical excipients, announced today an agreement to acquire IFF Pharma Solutions, a worldwide producer of excipients for oral dosage…
Co-release of paclitaxel and encequidar from amorphous solid dispersions increase oral paclitaxel…
The oral bioavailability of paclitaxel is limited due to low solubility and high affinity for the P-glycoprotein (P-gp) efflux transporter. Here we hypothesized that maximizing the intestinal paclitaxel levels through apparent solubility…