Phospholipid Complex-based Topical Gel for Codelivery of Erlotinib and Methotrexate in Psoriasis
Abstract
Topical drug delivery systems offer a targeted and patient-compliant approach for managing psoriasis, enabling noninvasive, localized, and sustained therapy, with reduced systemic side effects and improved therapeutic outcomes. In this study, we prepared phospholipid complex (PLC) based gel of methotrexate (MTX) and erlotinib (ERL) as a…
Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder
Abstract
Methods: Effervescent granules containing citric acid and sodium bicarbonate were successfully prepared for the first time via TS-MG using a polyol (sorbitol) as a melt binder.
Results: Processing parameters, specifically…
Formulation and Optimization of Fast Dissolving Thin Strips of Desvenlafaxine HCl by Using Quality…
Abstract
Aim
The present work was aimed to formulate and optimize fast dissolving thin strips of Desvenlafaxine Hydrochloride using QbD.
Materials and Methods
The solvent casting method was used to formulate fast dissolving thin strips.…
High Purity Phosphate Components for Biopharmaceutical Applications
Dr. Paul Lohmann proudly presents:
High Purity Phosphate Components for Biopharmaceutical Applications
Disodium Phosphate 2-hydrate and Potassium Dihydrogen Phosphate
Precisely coordinated buffer systems are indispensable…
Simultaneous Determination and Quantification of Nine Nitrosamine Impurities in Semi-Solid Forms…
Abstract
Many studies are being conducted on the detection of nitrosamine impurities in solid formulations. However, research on semi-solid formulations such as gels, ointments and creams is not common. In particular, excipients used to…
Phosphatidylcholine – More than just Choline
What is Phosphatidylcholine?
Phosphatidylcholine is the fat-soluble form of the vitamin-like substance choline and an important phospholipid for the human body. The molecule consists of a water-soluble choline head and two fat-soluble…
A bigel co-delivering highly hydrophilic and hydrophobic natural compounds for enhanced ulcerative…
Abstract
Bigel, formed by high-speed shearing of hydrogel and oleogel, is suited to deliver both lipophilic and hydrophilic active compounds. patchouli oil and paeoniflorin, despite their potential in treating ulcerative colitis, face…
Efficacy of Carbopol as an Adjuvant for Inactivated Rift Valley Fever Vaccine
Abstract
The purpose of the current study was to examine the immune response of sheep given the Rift Valley Fever virus vaccination adjuvanted with Carbopol®. Fifteen sheep were divided into three groups of five each. The first group…
Spectroscopic and Structural Investigations of Quercetin/Sulfobutylether-β-Cyclodextrin Inclusion…
Abstract
The present study deals with development and characterization of quercetin (QCT) – loaded sulfobutylether-β-cyclodextrin (SBE-β-CD) inclusion complex (IC) incorporated into eudragit S100 (ES100) nanofibers (NF) for colon specific…
Gattefossé achieves key milestone with new US plant certifications
Press Release, 14 Mar 2025
We, Gattefossé, proudly announce the successful certification of our new manufacturing plant in Lufkin, Texas.
The facility, operational since July 2024 with the first ingredients coming off our production…
Sustained Release Capsules Manufacturing and Handling
Patients and caregivers experience challenges following a prescribed medicine routine. If the active pharmaceutical ingredients (API) are released quickly then patients may require multiple doses of the drug. That is to maintain treatment…
A Novel Semi-Automated Pipeline for Optimizing 3D-Printed Drug Formulations
Abstract
3D printing offers a promising approach to creating personalized medicines. However, costly, expertise-dependent trial-and-error methods hinder efficient drug formulation, posing challenges for tailoring treatments to individual…
A framework for conducting clinical trials involving 3D printing of medicines at the point-of-care
Abstract
The integration of 3D printing (3DP) technologies into personalized medicine manufacture at the point-of-care is garnering significant interest due to its potential to create tailored drug products with precise dosages and other…
Hydrogels in Drug Delivery – Part 2
Hydrogels in Drug Delivery
See the new book, edited by Alejandro J. Paredes, Garry Laverty, Eneko Larrañeta, Ryan F. Donnelly. It covers the fundamental mechanisms of drug delivery from a hydrophilic matrix, breaks down interconnections…
Exploring the Impact of Formulation and Tablet Shape on Tablet Integrity: A Comprehensive…
Abstract
Tablets are subjected to collisions during processing and handling which can result in defects and even failed batches at commercial scale. This study investigated the influence of composition and tablet shape on the tablet…
Thermostabilization of a model viral-vectored oral thin film vaccine
Abstract
Vaccines rely on a global cold chain to maintain vaccine potency throughout the product life cycle. Existing vaccine thermostabilization methods like lyophilization and spray-drying impart significant stress on the vaccine,…
Unlocking the potential of microfluidic assisted formulation of exenatide-loaded solid lipid…
Abstract
Exenatide, a first-in-class GLP-1 receptor agonist, is used to control glycaemic levels in type 2 diabetes. There are two approved injectable formulations: one solution for immediate action and one dispersion for prolonged action.…
Influences of variations of the amount of compressed material on compressibility, tabletability and…
Abstract
Compression analysis is essential for the investigation of materials and processes in the manufacturing of pharmaceutical tablets. In the past, the influence of various process parameters on compression analysis has been…
Evaluating dosing accuracy and galenic dispersion quality in Hospital-Based pediatric spironolactone…
Abstract
Compounded oral suspensions of spironolactone are commonly used in pediatric patients with heart conditions. However, due to its poor solubility in water, spironolactone suspensions may lead to sedimentation, compromising…
Enhancing Capsule Formulations with High Bulk Density MCC: The Case of PURA Series™ Super Flow by…
In the fast-paced world of pharmaceutical manufacturing, excipients play a critical role in ensuring product quality, process efficiency, and patient compliance. One such excipient that continues to prove its value is microcrystalline…
3D printed tablets for personalised dose titration of prednisone using selective laser sintering
Abstract
The recent clinical emergence of 3D printing in pharmaceutical development has opened the possibility for a shift away from standardised medication dosing and towards more precise and personalised medicines and treatments.…
Cyclodextrin-based materials for pulmonary delivery: Insights and challenges
Abstract
Cyclodextrins (CDs) are cyclic oligosaccharides primarily used as excipients in the formulation of drugs, including those intended for pulmonary delivery. CDs have gained increased attention for their use as drug solubilizers. The…
Hydrogels in Drug Delivery – Part 1
Hydrogels in Drug Delivery
See the new book, edited by Alejandro J. Paredes, Garry Laverty, Eneko Larrañeta, Ryan F. Donnelly. It covers the fundamental mechanisms of drug delivery from a hydrophilic matrix, breaks down interconnections…
Tailored Biopolymer Capsules for Colon-Specific Drug Delivery: A 3D Printing Perspective
Abstract
The present study aims to develop capsules employing hot melt extrusion (HME) and fused deposition modeling (FDM) three-dimensional (3D) printing approach. The primary objective was to establish a colon drug delivery system (CDDS)…
Croda celebrates opening of expanded UK facility, bolstering global Super Refined™ capabilities
PRESS RELEASE, 12 May 2025
Croda International Plc (“Croda”), the company that uses smart science to create high-performance ingredients and pharmaceutical excipients that improve lives, celebrated the opening of its newly expanded Super…
Dissolve Pain in Seconds: The Advantage of F-MELT®in Lornoxicam Fast Disintegrating Tablets
Introduction
Revolutionizing Pain Relief for Rheumatoid Arthritis (RA)
Lornoxicam, a potent NSAID, is widely used for rapid pain relief in rheumatoid arthritis. However, its poor water solubility (BCS II) and bitter taste have…
Advances in the Oral Delivery of Protein and Peptide Drugs
Abstract
Protein and peptide drugs (PPDs) are highly effective therapies for a wide range of diseases, including cancer, diabetes, and autoimmune disorders . However, delivering these drugs orally presents significant challenges. PPDs face…
Deep learning-based image classification and quantification models for tablet sticking
Abstract
Sticking can significantly affect drug product quality, manufacturing efficiency, and therapeutic efficacy in pharmaceutical tablet manufacturing. This study presents a novel integrated model with a convolutional neural network…
The micro-structure of lactose powder compacts studied by small-angle and ultra small-angle X-ray…
Abstract
The objective was to derive indications of the microstructure of lactose powder compacts was studied by small-angle and ultra small-angle X-ray scattering experiments (SAXS/USAXS). Measurements were performed on a series of…
A novel peridynamics-based approach to predict pharmaceutical tablet robustness
Abstract
The pharmaceutical drug product development process can be greatly accelerated through the use of modeling and simulation techniques to predict the manufacturability and performance of a given formulation. The anticipation and…
Sulfur- and phosphorus-containing FDA approved drugs in the last five years (2020–2024): A journey…
Abstract
Sulfur and phosphorus are elements that can be found in various FDA-approved drugs, either as part of the active pharmaceutical ingredients (APIs) or as components of excipients (inactive ingredients). In this review we will…
Exploring mesoporous silica microparticles in pharmaceutical sciences: Drug delivery and therapeutic…
Abstract
Nanotechnology has revolutionised pharmaceutical sciences, with mesoporous silica nanoparticles (MSNs) extensively studied as drug carriers. However, their clinical translation is hindered by challenges such as toxicity, tumour…
Preparation of self-dispersible eutectic mixtures for poorly soluble drugs: Hot-melt extrusion vs.…
Abstract
Solid eutectic mixtures of self-dispersible polyethylene glycol-40-stearate with fenofibrate or ibuprofen—prepared by casting or by twin-screw extrusion—were compared in terms of processability and dissolution rate at, below, and…
Recent developments in nanofiber-based fast-disintegrating drug delivery systems
Abstract
Introduction
Fast-disintegrating electrospun fibers are emerging as innovative systems for oral drug delivery. These fibers possess a high surface area, porosity, and customizable hydrophilicity, which facilitates quick drug…
A universal digital control concept for end-to-end manufacturing
Abstract
With the implementation of advanced manufacturing concepts (e.g., continuous operation, integration of different process routes and modular manufacturing), control of the process and the related product quality becomes more…