Introducing Super Refined™ Poloxamer 188, optimised for mammalian cell culture in biomanufacturing

Croda announces the launch of their newest bioprocessing solution, developed to overcome batch-to-batch variation challenges in mammalian cell culture, offering the highest purity standards: Super Refined™ Poloxamer 188

Super Refined™ Poloxamer 188 is added to cell culture media to protect cells from shear stress caused by agitation in a bioreactor. Super Refined™ Poloxamer 188 has been optimised specifically for mammalian cell culture with tightly controlled impurity profiles and molecular weight, ensuring optimal cell culture performance and batch-to-batch consistency.

Consistent batch-to-batch performance is critical for dependable biomanufacturing

Poloxamer 188 is a well-known surfactant with a longstanding history of use as an excipient in pharmaceutical drugs. In the biomanufacturing space, it finds application not only as a surfactant for parenteral biological formulations, but also in mammalian cell culture as a shear stress protectant.

One persistent challenge in the market has been the search for reliable manufacturers of poloxamer 188 with the ability to produce consistent, reproducible materials, with dependable outcomes in biomanufacturing processes. In response to the growing demand for high performance, batch-to-batch consistent cell culture ingredients, Croda Pharma has developed Super Refined™ Poloxamer 188. Optimised specifically for cell culture during upstream bioprocessing, Super Refined™ Poloxamer 188 offers excellent cell culture performance with highly controlled impurity profiles that de-risk variable cell performance from batch-to-batch, ensuring consistency in performance and quality.

Introducing Super Refined™ Poloxamer 188, optimised for mammalian cell culture

As a product belonging to our Super Refined™ range, Super Refined™ Poloxamer 188 meets excellent purity standards, undergoes rigorous quality testing, is offered in enhanced packaging, and is also suitable for use as a parenteral excipient in biologic formulations.

• Batch-to-batch consistency in cell culture performance
• Exceptional performance in CHO and HEK suspension cell viability
• Consistency in poloxamer compositional and impurity profile
• Fast dissolution
• Controlled hydrophobic impurities
• Stringent quality testing
• Multi-compendial.

As the need for reliability and batch-to-batch consistency of bioprocessing materials becomes increasingly evident, Super Refined™ Poloxamer 188 may prove to be an effective solution in this field and set us apart as an integral supplier to the biomanufacturing space.

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Source: Croda, website “Introducing Super Refined Poloxamer 188, optimised for mammalian cell culture in biomanufacturing“

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