Solubility enhancement study of lumefantrine by formulation of liquisolid compact using mesoporous silica as a novel adsorbent

Lumefantrine, exhibits poor bioavailability due to its very low solubility. A liquisolid compact of lumefantrine was prepared with mesoporous silica as a novel coating material. Lactose anhydrous and syloid 244FP were selected as carrier and coating materials respectively. Varying the carrier to coating ratio from 10 to 35, six formulations were prepared and evaluated for tests for tablets.

Highlights

• Lumefantrine, a BCS class II drug, shows limited activity and low bioavailability.

• Liquisolid compact of lumefantrine is proposed with the use of Syloid 244FP.

• Amorphization of drug in liquisolid compact resulted enhanced solubility.

Thermal, surface characteristics, surface morphology, and surface area analysis. The tabletability of the formulation lactose to syloid 244FP ratio at 20:1 was found to be the best among all in terms of compression characteristics, faster disintegration, and enhanced dissolution. Hence it can be concluded that the use of a suitable amount of mesoporous silica in the formulation of liquisolid compact could significantly enhance the dissolution of the drug.

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Sayani Bhattacharyya, Daivanai Ramachandran, Solubility enhancement study of lumefantrine by formulation of liquisolid compact using mesoporous silica as a novel adsorbent, Materials Letters: X, Volume 16, 2022, 100171, ISSN 2590-1508, https://doi.org/10.1016/j.mlblux.2022.100171.