Synthesis, characterization of thiolated karaya gum and evaluation of effect of pH on its mucoadhesive and sustained release properties
Highlights
• Thiolated gum karaya was found to contain 5.026 mM of thiol groups/gm of polymer.
• Thiolation led to conjugates with improved properties than unmodified one.
• Swelling and mucoadhesion was increased with increase in pH from 1.2 to 6.8.
• TK tablets sustained the release of drug with no disintegration throughout study.
• Thiolation did not affect biocompatibility of the polymer.
http://www.sciencedirect.com/science/article/pii/S0144861715003902