Statistical Optimization of Fast Dissolving Tablet Contains Isosorbide Dinitrate for the Treatment of Angina Pectoris
Abstract
The ultimate objective about this experiment was to create a fast-dissolving tablet Isosorbide dinitrate that released its medication quickly. The physical properties of tablets, such as hardness, angle of repose, weight variation, and friability were assessed. In-vitro release was investigated, and a 22-factorial design was created. The results show that the in-vitro release shows that the F2 formulation has the highest release at 20 min. Tablet disintegration time ranges from 31 to 48 s. The hardness ranges from 6-7 kg/cm3. The friability test shows the range from 0.49-0.68%. The weight variation test shows that all the formulation passes the tests. ANOVA statistical analysis revealed that the generated formulations are statistically significant. It is concluded that FDT formulations have optimum and reproducible disintegration time and increased dissolve characteristics, resulting in higher patient compliance.
Introduction
Angina pectoris, a cardiovascular ailment, is identified by chest pain or discomfort brought on by an alteration in the amount of blood flowing to the heart. One of the drugs used for the treatment of this condition is Isosorbide dinitrate (ISDN), which belongs to the class of nitrate drugs. In order to increase blood flow to the heart and lessen the strain on the heart, ISDN works through dilation of blood vessels 1.
Fast dissolving tablets (FDTs) have emerged as an attractive dosage form for the treatment of angina pectoris because they offer several advantages, such as rapid onset of action, improved patient compliance, and ease of administration 2.
The design and development of FDTs of ISDN involves various aspects such as the selection of suitable excipients, optimization of the formulation, and evaluation of the product for its physicochemical properties, in vitro drug release, and stability.
Several techniques such as direct compression, freeze-drying, and spray drying have been used for the preparation of FDTs of ISDN. The choice of technique depends on the physicochemical properties of ingredients utilised.
The development of FDTs of ISDN may involve the use of superdisintegrants which aid the tablet’s quick breakdown in the mouth. Other excipients such as mannitol, sorbitol, and lactose may be used as bulking agents or sweeteners 3,4.
Overall, the aim of the study was to develop a fast dissolving tablet contains Isosorbide dinitrate for the treatment of angina pectoris and designing and development of ISDN FDTs is an important field of research with the potential to improve angina pectoris treatment by providing a more convenient and effective dose form.
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Materials
Isosorbide dinitrate (Abbott, India), Microcrystalline cellulose (Yarrow chem, India), Sodium starch glycolate (Yarrow chem, India), Crocarmellose sodium (Yarrow chem, India), Talc (Yarrow chem, India).
Salam S, Fathima R, Sreelekha P. P, Kavya M, Anjali E. Statistical Optimization of Fast Dissolving Tablet Contains Isosorbide Dinitrate for the Treatment of Angina Pectoris. Biotech Res Asia 2023;20(4).
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