Drug delivery innovation: Vitamin E TPGS and Polyamino acids
Vitamin E TPGS, a water soluble derivative of natural Vitamin E, is a multirole excipient for pharmaceutical drug delivery innovation. Vitamin E TPGS is a non-ionic surfactant used as:
- solubilizer of poorly soluble drugs
- absorption enhancer
- emulsifier
- vehicle for lipid-based drug formulation
- antioxidant
Vitamin E TPGS is also used as an efficient source of natural Vitamin E both for therapeutic and nutrition purposes.
Regulatory
A National Formulary (NF) monograph is in the United States Pharmacopeia / National Formulary (USP/NF) version USP 40 – NF 35. Several commercial drugs using Vitamin E TPGS are approved by FDA and EMEA, PMDA.
Vitamin E TPGS in drug formulation
Formulation fields:
Vitamin E TPGS has been used mainly in oral dosage forms for years but new delivery applications are being investigated in parenteral, nasal, ophthalmic, dermal deliveries
Benefits:
- Enhancement of Bioavailability by increasing solubility of poorly water-soluble APIs and by formulation of Self Emulsifying Drug Delivery System (SEEDS)
- Thermal stability for hot melt extrusion as a versatile plasticizer with solubilizer properties and as Antioxidant for sensitive excipients
Related Articles
Track records:
Formulation using TPGS has been developed for commercial drugs :
- Two anti HIV drugs, AGENERASE® (Amprenavir) soft gel capsules and oral solution and APTIVUS® (Tripanavir) oral solution
- One anti HCV drug, VIEKERA Pack™ (combination of 3 APIs) tablets
Amino acid based biopolymer diversity for innovative therapies
Why a polyaminoacid based delivery technology?
- Growing interest for advanced biomedecines
- Biocompatibility and biodegradability
- Chemical & Architectural Versatility of Polyamino acids
- Many therapeutic areas: Immunotherapy, Oncology, Gene Therapy, Inflammatory, Neurodegenerative, Infectious, Diagnosis, Skin care…
Which delivery technology?
A biomaterial toolbox for various Nanotechnologies and Drug Conjugates
What polymeric structure?
