Drug delivery to the intestinal lymph by oral formulations

25. January 2022

Oral drug delivery systems (DDS) targeting lymphocytes in intestinal lymphatic vessels, ducts, and nodes are useful for treating diverse diseases....

100% visual inspection of tablets produced with continuous direct compression and coating

16. January 2022

Visual appearance of tablets is an important property for patients. Since the visual appearance is most strongly influenced by the...

Fig. 2. Unit operations in the direct compaction line including (a) loss-in-weight feeders and the continuous blender, (b) the tablet press with the ECVT powder mass flow measurement at the inlet and weigh scale-based tablet production rate measurement at the outlet, and (c) the hopper associated with the tablet press with a camera and image analysis-based level measurement system.

Real-Time Monitoring of Powder Mass Flowrates for Plant-Wide Control of a Continuous Direct Compaction Tablet Manufacturing Process

16. January 2022

While measurement and monitoring of powder/particulate mass flow rate are not essential to the execution of traditional batch pharmaceutical tablet...

Fig. 2. Cumulative percent probability curves for the physiological parameters in the gastrointestinal tract in the PK simulations.

Towards Virtual Bioequivalence Studies for Oral Dosage Forms Containing Poorly Water-Soluble Drugs: A Physiologically Based Biopharmaceutics Modeling (PBBM) Approach

15. January 2022

The objective of the present study was to develop a physiologically based biopharmaceutics (PBBM) approach to predict the bioequivalence of dosage forms...

graphical abstract of Better and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable solid dosage forms

Better and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable solid dosage forms

15. January 2022

In the last decades, Green Chemistry has been gaining widespread attention within the pharmaceutical field. It is thus very important...

Performance Evaluation of Montelukast Pediatric Formulations: Part II — a PBPK Modelling Approach

13. January 2022

This study aimed to build a physiologically based pharmacokinetic (PBPK) model coupled with age-appropriate in vitro dissolution data to describe drug performance...

Review of paediatric gastrointestinal physiology relevant to the absorption of orally administered medicines

29. December 2021

Despite much progress in regulations to improve paediatric drug development, there remains a significant need to develop better medications for...

graphical abstract of Oral administration of buparvaquone nanostructured lipid carrier enables in vivo activity against Leishmania infantum

Oral administration of buparvaquone nanostructured lipid carrier enables in vivo activity against Leishmania infantum

26. December 2021

Leishmaniasis, a neglected tropical disease, is prevalent in 98 countries with the occurrence of 1.3 million new cases annually. The...

Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters

25. December 2021

Press-coated tablets are a high-interest technology in chronopharmaceutics, for modified release applications. As for any kind of tablet, the test...

Machine Learning and Machine Vision Accelerate 3D Printed Orodispersible Film Development

22. December 2021

Orodispersible films (ODFs) are an attractive delivery system for a myriad of clinical applications and possess both large economical and...

Oral Excipients