Pharma Excipients
Orally Dissolving Technology Excipient
Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets…
A majority of therapeutics are not available as suitable dosage forms for administration to pediatric patients. The first part of this review provides an overview of clinical and technological challenges and opportunities in the development of child-friendly dosage forms such as taste masking,…
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Development and Optimization of Sildenafil Orodispersible Mini-Tablets (ODMTs) for Treatment of…
The availability of age-appropriate oral dosage forms for pediatric patients has remained a challenge. Orodispersible mini-tablets (ODMTs) are a promising delivery system for pediatric patients. The purpose of this work was the development and optimization of sildenafil ODMTs as a new dosage form…
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Effect of co-processed excipient type on properties of orodispersible tablets containing captopril,…
An important feature of orodispersible tablets (ODTs) is the convenient administration of the drugs, in some cases, faster onset of action, stability maintenance, and dose precision. This work focused on the preparation of ODTs containing mannitol-based co-processed excipients Prosolv® ODT G2,…
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Bioequivalence Dissolution Test Criteria for Formulation Development of High Solubility-Low…
The purpose of the present study was to provide the experimental and theoretical basis of bioequivalence (BE) dissolution test criteria for formulation development of high solubility-low permeability drugs. According to the biowaiver scheme based on the biopharmaceutics classification system (BCS),…
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Formulation of taste-masked orodispersible famotidine tablets by sequential spray drying and direct…
Since famotidine (FA) is prescribed for gastrointestinal diseases orodispersible tablets could contribute to patients’ compliance. Its bitter taste and poor compressibility pose formulation challenges which were addressed in this study. Famotidine/mannitol (FA/MA) binary solution was spray dried…
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Introducing the application of F-Melt® for manufacturing oral disintegrating tablets (ODTS) of…
See the fifth issue of Fuji Chemical Industries Technical Newsletter. It presents the application of F-Melt® for manufacturing oral disintegrating tablets (ODTS) of Simvastatin.
ORAL DISINTEGRATING TABLETS OF SIMVASTATIN WITH F-MELT®
F-Melt® is a co-processed spray-dried excipient system…
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3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients
Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating printlets (ODPs) suited for patients with visual impairment. Printlets…
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Orally disintegrating drug carriers for paediatric pharmacotherapy
Non-compliance, dosing inaccuracy, choking risk, flavour, and instability, are some of the issues associated with paediatric, oral dosage forms — tablets, capsules, solutions, and suspensions. Orally disintegrating drug carriers, a dosage form with growing interest, are thought to overcome several…
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Formulation and Characterisation of Carbamazepine Orodispersible 3D-Printed Mini-Tablets for…
Abstract
One of the main challenges to paediatric drug administration is swallowing difficulties, hindering the acceptability of the medicine and hence clinical outcomes. This study aims at developing a child-appropriate dosage form, the orodispersible mini-tablet (ODMT), using the model drug…
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Advances in Formulation and Manufacturing Strategies for the Delivery of Therapeutic Proteins and…
Therapeutic proteins and peptides (TPPs) are increasingly favoured above small drug molecules due to their high specificity to the site of action and reduced adverse effects resulting in increased use of these agents for medical treatments and therapies. Consequently, there is a need to formulate…
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