ABSTRACT

Six batches of formulated sustained release matrix tablets of Cefixime Trihydrate were prepared by using different polymers like Tamarind Gum, Carnauba wax, HPMC, MCC, PVP K30 by wet granulation technique. The effects of prepared tablets by using natural polymers were evaluated for pre compression parameters, uniformity of content, assay and in vitro drug release. Influences of different parameters like pH, agitation intensity on drug release were also studied. Cefixime Trihydrate sustained release matrix tablets prepared using HPMC and carnauba wax was observed a better system for once-daily sustained release of a water-soluble drug like Cefixime Trihydrate which effectively release more than 100% for 12 hrs. All the prepared formulations (F01 to F06) were fitted in to zero order, first order, Higuchi’s model and Korsemeyer-peppas model and the values of slope, intercept and r2 were calculated. The r2 values were found to be 0.9925(F05) and 0.9941(F06) for Higuchi’s release model & 0.9792 for first order release model. The r2 values were found to be 0.9747(F04) for zero order release model. The formulations are following Higuchi’s release model. Hence it is suggested that the drug was released by Fickian diffusion in all the cases.

Keywords: Carnauba wax, Tamarind gum, Matrix tablets, Cefixime Trihydrate, Higuchi’s release model