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      • Calcium Carbonate
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      • Calcium Sulfate
      • Halites
      • Metallic Oxides
      • Silica
    • Organic Chemicals
      • Actual Sugars
      • Artificial Sweeteners
      • Carbohydrates
      • Cellulose
      • Cellulose Esters
      • Cellulose Ethers
      • CMC and Croscarmellose Sodium
      • Converted Starch
      • Dried Starch
      • Microcrystalline Cellulose
      • Modified Starch
      • Starch
      • Sugars
      • Sugar Alcohols
    • Petrochemicals
      • Acrylic Polymers
      • Glycols
      • Mineral Hydrocarbons
      • Mineral Oils
      • Mineral Waxes
      • Petrolatum
      • Polyethylene Glycol (PEG)
      • Povidones
      • Propylene Glycol
      • Other Petrochemical Excipients
    • Oleochemicals
      • Fatty Alcohols
      • Glycerin
      • Mineral Stearates
      • Pharmaceutical Oils
      • Other Oleochemical Excipients
    • Proteins
  • Applications
    • 3D Printing – Drug Carrier
      • 3D Printing
      • Binder
      • Coating
      • Colour / Color
      • Coating Systems and Additives
      • Controlled Release Excipient
      • DC excipient
      • Disintegrant / Superdisintergrant
      • Drug Carrier
    • Emulsifier – Glidant
      • Emulsifier
      • Excipient for Inhalation
      • Filler
      • Film former
      • Flavour / Flavor
      • Glidant
    • Lubricant – Preservative
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      • Nanotechnology
      • Orally Dissolving Technology Excipient
      • Pellet
      • Plasticizer
      • Preservative
    • Solubilizer – Viscocity Agent
      • Solubilizer
      • Speciality Excipient
      • Surfactants
      • Suspension Agent
      • Sustained Release Agent
      • Sweeteners
      • Taste Masking
      • Topical Excipient
      • Viscosity Agent
  • Sources
    • Handbook of Pharmaceutical Excipients – 9th Edition
    • EINECS Numbers
    • Excipient DMF List
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    Sigachi
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Startseite » Organic Chemicals » Cellulose » Surface engineered excipients:II. Simultaneous milling and dry coating for preparation of fine-grade microcrystalline cellulose with enhanced properties

Surface engineered excipients:II. Simultaneous milling and dry coating for preparation of fine-grade microcrystalline cellulose with enhanced properties

15. May 2018
Surface engineered excipients:II. Simultaneous milling and dry coating for preparation of fine-grade microcrystalline cellulose with enhanced properties

15. May 2018

Asolventless process for simultaneously milling and dry coating microcrystalline cellulose (MCC) was investigated for producing fine excipients in five different sizes (∼20, 25, 30, 35, 40µm) havinghigh bulk density (BD), good flow function coefficient (FFC), and excellent compaction. Avicel PH-102, used as the starting material, was milled and coated with two grades of silicas, hydrophobic andhydrophilic (R972P and A200), using a fluid energy mill (FEM). Through judicious selection of the FEM feed rate, feeding pressure, and grinding pressure, five desired milled sizes were produced. Thebulk density of all the milled-coated (1wt% A200) excipients was significantly better than uncoated-milled MCC, Avicel PH-102, and Prosolv 50 and 90. Whereas the FFC values were greater thanuncoated-milled MCC, Avicel PH-102, and Prosolv 50 (latter for ∼30, 35, and 40µm sizes). The tablet compaction testing was used to evaluate compactibility (tensile strength vs tablet porosity),compressibility (tablet porosity vs compaction pressure), and tabletibility (tensile strength vs compaction pressure). The results indicate that all finer grade milled and A200 coated MCC had lower porosity and higher tablet strengths than Prosolv 50 and 90 at all compaction pressures. Surprisingly, the BD and FFC were better for A200 than for R972P coated-milled MCCs; explained through analyzing inter-particle contact models. Finally, milling did not increase the moisture content but coating with silica led to a slight increase; A200 higher than R972P. It is hoped that these engineered excipients would help formulators with a multitude of options for finer excipients without loss of flow and bulk density.


Read on in ScienceDirect
Graphic with production overview and results of surface engineered excipients
Surface engineered excipients: production and analysis results

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    • 3D Printing – Drug Carrier
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      • Coating
      • Colour / Color
      • Coating Systems and Additives
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      • Drug Carrier
    • Emulsifier – Glidant
      • Emulsifier
      • Excipient for Inhalation
      • Filler
      • Film former
      • Flavour / Flavor
      • Glidant
    • Lubricant – Preservative
      • Lubricant
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      • Orally Dissolving Technology Excipient
      • Pellet
      • Plasticizer
      • Preservative
    • Solubilizer – Viscocity Agent
      • Solubilizer
      • Speciality Excipient
      • Surfactants
      • Suspension Agent
      • Sustained Release Agent
      • Sweeteners
      • Taste Masking
      • Topical Excipient
      • Viscosity Agent
  • Sources
    • Handbook of Pharmaceutical Excipients – 9th Edition
    • EINECS Numbers
    • Excipient DMF List
    • Excipient cGMP Certification Organisations
    • FDA Inactive Ingredient List
    • FDA GRAS Substances (SCOGS) Database
    • Excipient E-Numbers
    • Whitepapers / Publications
    • Contract Development|Contract Manufacturing
  • Suppliers
    • A-B
      • ADM
      • ARMOR PHARMA
      • Ceolus™ & Celphere™
      • Ashland
      • BASF
      • Beneo – galenIQ
      • Biogrund
      • Budenheim
    • C-G
      • Captisol
      • Croda
      • Cyclolab
      • DFE Pharma
      • DuPont Pharma Solutions
      • Evonik
      • Fuji Chemical Industries
      • Gattefossé
      • Gangwal Healthcare
    • I-O
      • ingredientpharm
      • IOI Oleochemical
      • JRS Pharma
      • Kerry
      • KLK Oleo Life Science
      • Lactalis Ingredients Pharma
      • Lipoid
      • Dr. Paul Lohmann
      • Lubrizol
      • Magnesia
      • MEGGLE Excipients
      • Nagase Viita – Pharmaceutical Ingredients
      • Nordic Bioproducts Group
    • P-Z
      • Pfanstiehl
      • pharm-a-spheres
      • Pharma Line
      • PMC Isochem
      • Roquette Pharma
      • Seppic
      • Shin-Etsu
      • Sigachi Group
      • Südzucker AG
      • VIKRAM THERMO
      • Zerion Pharma
      • ZoomLab® – Your Virtual Pharma Assistant
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      • Tailored Film Coating
  • Events
    • Overview Pharmaceutical Webinars
    • Videos CPhI Frankfurt 2025
    • CPhI China 2024
    • ExciPerience – The great excipient event!
  • All4Nutra

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Copyright: PharmaExcipients AG