Sugar Alcohols

Epilepsy is the most common chronic brain disorder and affects millions of people worldwide. Carbamazepine (CBZ) is one of the first-line pharmacological therapy instituted to patients due to its wide spectrum of action. Although marketed for more than 30 years, CBZ efficacy is strongly limited by…
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Chitosan has excellent properties, as it is nontoxic, mucoadhesive, biocompatible, and biodegradable. However, the poor water solubility of chitosan is a major disadvantage. Here, a novel chitosan-sodium carbonate complex was formed by adding a large amount of sodium carbonate to a chitosan/acetic…
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In the design of the orally disintegrating films (ODFs), it is important to determine the disintegration time (DT) precisely and properly. These films’ DTs are usually assessed by a disintegration test defined in the pharmacopoeias, but under the conditions of such tests, a much larger volume of…
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Increasing patient adherence to medication regimens remains a top priority in the pharmaceutical industry. Simultaneously, consumers/patients are looking for dosage forms that are easy to take and that will not disrupt their everyday “on the go” lifestyle. Orally disintegrating tablets (ODTs) can…
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galenIQ™ is a soluble filler-binder characterized by its ease of use and applicability to a wide range of solid and liquid medicine such as tablets, sachets, lozenges and syrups. The main reason it works is its delicate sweetness. Read more about the application and key benefits of galenIQ™ on our…
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A compatibility study of drug substance with excipients is a crucial step in the drug development process in order to generate potent final drug formulations for efficient and safe therapy for various diseases. Thus, the development of new methods for compatibility studies is a great challenge. For…
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The aerodynamic performance of a dry powder for inhalation depends on the formulation and the dry powder inhaler (DPI). In the case of capsule-based DPIs, the capsule also plays a role in the powder aerosolisation and the dispersion of the micronized drug during the inhalation. This study evaluated…
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A study was conducted to evaluate mannitol as a filler along with microcrystalline cellulose (MCC) in wet granulated tablet formulation, in situations in which lactose cannot be included in the formulation because of chemical incompatibility with the active drug. A two-level full factorial design…
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Tobramycin (TOB) and clarithromycin (CLA) can potentially be used synergistically for the treatment of respiratory infections caused by Pseudomonas aeruginosa (P. aeruginosa) in cystic fibrosis (CF) patients. This study aimed to develop a novel combination proliposome formulation (TOB/CLA-CPROLips)…
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The comparison of spray drying versus hot melt extrusion (HME) in order to formulate amorphous solid dispersions has been widely studied. However, to the best of our knowledge, the use of both techniques to form cocrystals within a carrier excipient has not previously been compared. The combination…
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