Trehalose

The oral bioavailability of therapeutic proteins is limited by the gastrointestinal barriers. Encapsulation of labile proteins into nanoparticles is a...

Pfanstiehl (IL, USA) is a global leader in developing High Pure/Low Endotoxin Viral Vector, Protein and Vaccine stabilizers ( eg....

The properties of trehalose + water mixtures are studied as a function of mixture composition and temperature using molecular dynamics...

We have observed an interesting phenomenon in which grinding of freeze-dried monoclonal antibody X (mAb-X) formulation powder resulted to significant...

Freeze-drying, until now, has been a process that was designed using a trial and error experimental approach. This approach is...

Drying of coacervates can cause various stresses which may lead to the damage of the outer layer membrane, aggregation, and...

Intracellular/extracellular protein aggregation is linked to variety of neurodegenerative diseases. Current research focusses on identifying anti-amyloidogenic small molecules to inhibit...

Localized aerosol delivery of gene therapies is a promising treatment of severe pulmonary diseases including lung cancer, cystic fibrosis, COPD...

Spray drying biologics and small-molecule drugs can increase their thermal stability relative to liquid dosage forms and allow for widespread...

Two enveloped viral vectors, vesicular stomatitis virus and influenza virus, and a non-enveloped viral vector, human adenovirus type 5, were...