Polysorbates

Abstract The transdermal delivery of large molecules such as proteins and vaccines faces enormous challenges and at the same time...

Abstract Proteolysis targeting chimeras (PROTACs) are heterobifunctional degraders with a unique mode of action that permits access to “undruggable” targets....

Abstract Lyophilization enhances mRNA vaccine stability, but conventional approaches using external trehalose for lipid nanoparticle (LNP) colloidal stability neglect mRNA...

Abstract Posaconazole (PCZ) is a broad spectrum anti-fungal drug approved by FDA and currently used off-label for the treatment of...

Abstract The quality attributes of pharmaceutical products have been affected by the duration of manufacturing processes; therefore, manufacturers use various...

Abstract Poor aqueous solubility may decrease the absorption and oral bioavailability of lipophilic drugs. In the current study, artemether (ART)...

Abstract Traditional extemporaneous compounding methods of solid oral dosage forms required in early-stage studies are laborious, and the drug’s solid...

Abstract Similar to other routes of administration, pulmonary formulations typically contain excipients. The panel of substances that can be used...

Enhancing the oral delivery of poorly water-soluble drugs remains a key challenge in pharmaceutical development. Lipid-based self-emulsifying drug delivery systems...

Abstract Aerosolized lipid nanoparticles (LNPs) delivering mRNA are an attractive strategy for use in local, inhalable therapy to treat patients...