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Labrafil M 2130 CS

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Description

A solid co-emulsifier in topical formulations to improve stability of emulsions. A nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly soluble APIs. Self-emulsifies in aqueous media forming a coarse dispersion, i.e., emulsion (SEDDS).

Main functionalities: Co-emulsifier in topical formulations often associated with Tefose® 63. Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion—LFCS Type II (SEDDS). Combine with Labrasol® ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS). Safety of use is inferred by substantial toxicological data and precedence of use in approved pharmaceutical products.

Additional information

Manufacturer

Gattefosse
Quality

USP-NF/EP
Composition

Consists mainly of mono-, di- and triglycerides and PEG-6 (MW 300) mono- and diesters of lauric (C12) and stearic (C18) acids
Dosage Form

Oral
Function

Topical emulsion, microemulsion, and foam. Self-emulsifying lipid formulation for oral applications. Capsule molding.
Compendial Name

HYDROGENATED PALM/PALM KERNEL OIL PEG-6 ESTERS, Lauroyl macrogol-6 glycerides, Lauroyl polyoxyl-6 glycerides
Cas-No

57107-95-6
Einecs

NOT- AP-PL.

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