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LIPOID S 80

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Description

Oral Applications

Phospholipids – to improve the oral absorption of active ingredients

In oral applications phospholipids aim to enhance oral uptake and bioavailability of poorly water-soluble drug substances. They can reduce irritation of the stomach or help to protect the API from degradation.

The phospholipids are mainly applied in emulsions, dispersions, mixed micelles, (pro) liposomes, solid dispersions, and non-aqueous phospholipid formulations. They can serve as wetting agents, emulsifiers, solubilizers, or lipid matrix forming excipients. Such formulations can be converted into dry forms such as granules, powders, and tablets by adding appropriate excipients or directly filled, e.g., into capsules, sachets, or bottles.

Liquid Phospholipid Formulations
Liquid, non-aqueous concentrates of phospholipids in combination with oils or a water-miscible solvent like propylene glycol are suitable for dissolving APIs. Diluted in water, they help to disperse the API in the aqueous phase. They  may be directly filled into capsules, bottles, or sachets as dosage form.

Emulsions
When the drug has sufficient solubility in oils, O/W emulsions or self-emulsifying systems can be prepared with phospholipids as emulsifiers or co-emulsifiers.

(Mixed) Micelles
(Mixed) Micelles comprising phospholipids and bile salts mimic natural gut solubilization systems and are valued solubilizers, even for pediatric use.

Solid Dispersions
A poorly soluble API and a phospholipid, for example, spray-dried with or without polymers, form solid dispersions with the amorphous state of the drug. Upon hydration, the phospholipids act as wetting agents and solubilizers.

Phospholipids as API’s
Polyunsaturated/Polyenyl Phospholipids (PPL) derived from soybean are used for the prevention and treatment of liver diseases. These phospholipids suppress the formation of detrimental Radical Oxygen Species (ROS). They are available either as soybean phospholipid raw material or as formulated liquid products.

The products shown below represent a selection of our extensive product range.

Starting from crude soybean lecithin, purified soybean phospholipids fulfill manifold functions in pharmaceutical, cosmetic, or health nutrition applications. These highly defined products show excellent performance as wetting agents, solubilizers, emulsifiers, liposome builders, and as technical aids. Beside this, they are also a source of choline and essential fatty acids. Most products are available in non-GMO quality.

Additional information

Manufacturer

Lipoid
Composition

PPL Phospholipids with 73 – 79 % phosphatidylcholine
Dosage Form

all types of dosage forms
Cas-No

CAS-No. 8030-76-0
Function

Oral Application, source of choline and essential fatty acids, wetting agents, solubilizers, emulsifiers, liposome builders, and as technical aids
Synonym

Soybean Phospholipids

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