Pullulan

Thesis findings 1. Acetylsalicylic acid (ASA) was synthesized in continuous flow reactors for the first time. Design of experiment studies were conducted in order to optimize the two synthetic steps: i.e. the acetylation of salicylic acid (SA) and the quenching of impurities. By applying the…
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The aim of this study was to prepare pullulan-based orally disintegrating films (ODFs) containing amlodipine besylate, an anti-hypertensive drug, by the solvent casting method. For this purpose, nine different ODF formulations (F1-F9) were prepared by using different plasticizers (glycerol,…
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Active packaging incorporating antioxidants and antimicrobials is creating a niche in the market and becoming increasingly important. The main goal of this work was the design of bioactive bilayer films (zein/pullulan) incorporating licorice essential oil. The bilayer films were fully characterized…
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Edible polymers refer to the polymeric materials which can be consumed by human beings, animals or microorganisms without any noxious effects towards health. They are categorized into polysaccharides, proteins and lipids, and have gained increasing application mainly in functional food industries…
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Child-appropriate dosage forms are critical in promoting adherence and effective pharmacotherapy in pediatric patients, especially those undergoing long-term treatment in low-resource settings. The present study aimed to develop orodispersible films (ODFs) for isoniazid administration to children…
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The moisture sorption and desorption properties of hard capsules have a great influence on the quality of capsule products. However, studies on them have rarely been reported. Herein, we studied the moisture sorption and desorption properties of three kinds of hard capsules (gelatin, hydroxypropyl…
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Spray drying biologics and small-molecule drugs can increase their thermal stability relative to liquid dosage forms and allow for widespread distribution to developing countries without cold chain infrastructure. In this study, pullulan trehalose powder is spray dried for inhalation. The powder…
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